有氧耐力可训练性差异与运动适应性循环microRNA表达谱特征的关联性  

Correlation between aerobic endurance trainability difference and the expression spectrum characteristics of sport adaptive circulating microRNA

作　　者：薛源[1] 李岩[2] 徐思[3] 

机构地区：[1]四川师范大学体育学院,四川成都610101 [2]鲁东大学体育学院,山东烟台264025 [3]四川省医学科学院四川省人民医院,四川成都610031

出　　处：《体育学刊》2015年第4期139-144,共6页Journal of Physical Education

基　　金：科技部科技奥运专项"提高体能类项目优秀运动员竞技能力关键技术的研究"(2005BA904);四川省教育厅项目"运动训练过程中NKT细胞机能水平与运动疲劳程度的相关性研究"(11SA055)

摘　　要：mi RNA调控机体对训练应激的适应能力,其调控模式影响有氧耐力可训练性。循环mi RNA(c-mi RNA)与mi RNA密切相关,分析不同有氧耐力可训练性水平群体的运动适应性c-mi RNA表达变化差异,可获得与训练敏感性相关的c-mi RNA表达谱特征。结果显示:高可训练性表型在有氧训练应激诱导下差异表达17条c-mi RNA,其中11条上调,6条下调或平稳,其调控功能主要涉及低氧适应通路和脂肪酸β氧化代谢的关键基因表达。提示:有氧耐力可训练性差异与机体低氧适应能力和脂肪酸β氧化供能能力,对有氧训练应激诱导作用的反应性密切相关。mi RNA调控并整合机体应激适应性基因表达。c-mi RNA差异表达谱可用来评估有氧耐力可训练性,预测有氧能力发展潜力。miRNA regulates the body＇s ability to adapt to training stress; its regulating pattern affects aerobic en- durance trainability. Circulating miRNA （c-miRNA） is closely related to miRNA; by analyzing differences in the changing of sport adaptive c-miRNA expression of groups of people at different aerobic endurance trainability lev- els, the authors can acquire the expression spectrum characteristics of c-miRNA sensitively correlative with training. Results： induced by aerobic training stress, the phenotype with high trainability differentially expressed 17 c-miRNAs, 11 of which were up-regulated, 16 of which were down-regulated or steady, its regulating function mainly involved with hypoxia adaptation pathway and the key gene expression of fatty acid β-oxidation metabolism. Hint： aerobic endurance trainability difference is close related to the reactivity of the body＇s hypoxia adaptation ability and fatty acid β-oxidation energy supply ability to the induction function of aerobic training, miRNA regulates and in- tegrates the body＇s stress adaptive gene expression. C-miRNA differential expression spectrum can be used to evaluate aerobic endurance trainability, and to predict aerobic ability development potential.

关 键 词：运动生物化学 有氧耐力 可训练性 循环微核苷酸 最大摄氧量 关联模型 运动性适应 

分 类 号：G804.7[文化科学—运动人体科学]