Survivin和OPN在不同宫颈病变组织中的表达及相关研究  

Expressions and Related Studies of Survivin and OPN in Different Cervical Lesions

作　　者：王艳书[1] 鲁静[2] 李海燕[1] 

机构地区：[1]大理学院,云南大理671000 [2]保山中医药高等专科学校,云南保山678000

出　　处：《大理学院学报（综合版）》2015年第8期49-52,共4页Journal of Dali University

基　　金：云南省教育厅科研基金一般项目(2014Y400)

摘　　要：目的:探讨Survivin、OPN在慢性宫颈炎、宫颈上皮内瘤(CIN)、宫颈鳞癌组织中的表达情况。方法:采用免疫组织化学SP法检测Survivin、OPN在10例慢性宫颈炎、20例宫颈上皮内瘤变Ⅲ期(CINⅢ)和50例宫颈鳞癌组织中的表达情况。结果:Survivin和OPN在慢性宫颈炎、CINⅢ、宫颈鳞癌中的表达阳性率均随病变严重程度逐级增强,3组比较差异均有统计学意义(P<0.05)。Survivin的表达阳性率与宫颈鳞癌的临床分期、病理分级有关(P<0.05),与年龄、有无淋巴结转移无关(P>0.05);Survivin的表达阳性率与宫颈鳞癌的临床分期、有无淋巴结转移有关(P<0.05),与年龄、病理分级无关(P>0.05)。结论:Survivin+OPN的联合检测有可能作为宫颈鳞癌的早期诊断、病情监测和预后判断的指标。Objective： To discuss the expressions of Survivin and OPN in the tissues of chronic cervitis, cervical intraepithelial neoplasia （CIN） and cervical squamous carcinoma. Methods： Immunohistochemical SP method was applied to detect the expressions of Survivin and OPN in 10 cases of chronic cervicitis, 20 cases of CIN and 50 cases of cervical cancer. Results： The expression positive rate of Survivin and OPN in chronic cervicitis, CIN Ⅲ, cervical squamous carcinomas increased with the lesion severity level enhancement, three groups of comparative differences are statistically significant （P 〈 0.05）. The expression positive rate of Survivin in cervical squamous carcinomas was associated with clinical stages and pathologic stage （P 〈 0.05）, but has nothing to do with age and lymph nodes metastasis （P〉0.05）. The expression positive rate of OPN in cervical squamous carcinomas was associated with clinical stages and lymph node metastasis （P 〈 0.05）, but has nothing to do with age and pathologic stage （P 〉 0.05）. Conclusion： The joint detection of Survivin and OPN may serve as the index for early diagnosis, condition monitoring and prognosis judgment of cervical squamous carcinomas.

关 键 词：SURVIVIN OPN 免疫组化 慢性宫颈炎 宫颈上皮内瘤 宫颈鳞癌 

分 类 号：R737.33[医药卫生—肿瘤]