内侧颞叶癫痫术后认知功能长期追踪研究  

LONG-TERM FOLLOW-UP STUDY OF POSTOPERATIVE COGNITIVE FUNCTION FOR MEDIAL TEMPORAL LOBE EPILEPSY

作　　者：刘学政[1] 肖贱英[1] 谭立宇[1] 陈富勇[2] 

机构地区：[1]井冈山大学临床医学院,江西吉安343000 [2]福建医科大学附属第一医院,福建福州350005

出　　处：《井冈山大学学报（自然科学版）》2015年第4期80-83,共4页Journal of Jinggangshan University (Natural Science)

基　　金：江西省科技支撑计划项目(20111BBG70019-3)

摘　　要：目的探讨手术治疗对内侧颞叶癫痫认知功能的长期影响。方法选择32例内侧颞叶癫痫患者,并行前颞叶及内侧结构切除手术治疗,分别于术前、术后1月、术后半年、术后1年、术后1年半及术后2年对患者认知功能进行神经生理学评价,统计分析语言智商、操作商、记忆商和总智商的变化规律。结果内侧颞叶癫痫患者术后1月与术前比较语言智商、记忆商下降(P<0.05),而操作商和总智商无差异(P>0.05);术后半年语言智商、操作商和总智商与术前比较有明显改善(P<0.05),记忆商仍下降;术后1年、术后1年半、术后2年患者的语言智商、操作商、记忆商和总智商处于一个相对稳定的水平,与术后半年比较无差异(P>0.05)。结论手术治疗能部分改善内侧颞叶癫痫患者的认知功能,手术后半年认知功能改善明显。Objective：To investigate the postoperative cognitive function for medial temporal lobe epilepsy. Methods：32 medial temporal lobe epilepsy patients were resected away with anterior temporal lobe and the medial structures. All subjects were done with cognitive function neurophysiological evaluation on preoperative and postoperative 1 month, six months, 1 year, 1 and a half years, 2 years to analyze the change rules of language IQ, operation IQ, memory IQ and total IQ scores.Results： The language IQ and memory IQ scores of the patients for postoperative 1 month declined than those for preoperative with the medial temporal lobe epilepsy（P〈 0.05）, but it was not significantly different for operation IQ and total IQ scores. The language IQ, operation IQ and total IQ score for postoperative six month were significantly increased than those for preoperative （P 〈 0.05）. However, memory IQ score declined. The language IQ, operate IQ, memory IQ and total IQ scores were at relatively stable level on postoperative 1 year, 1 and a half years, 2 years. It was not significantly different for postoperative six month （P 〉 0.05）.Conclusion： Surgical treatment can improve part cognitive function of patients with the medial temporal lobe epilepsy. Cognitive function was significantly improved after postoperative half year.

关 键 词：内侧颞叶癫痫 手术治疗 认知功能 长期追踪 

分 类 号：R742.1[医药卫生—神经病学与精神病学]