子宫内膜息肉术后放置左炔诺孕酮宫内释放系统对IGF-1的影响研究  

The study of effect of levonorgestrel intrauterine system on the expressions of insulin-like growth factor-1 with endometrial polyps

作　　者：陶跃平 吴晓杰[1] 

机构地区：[1]浙江省嘉兴市妇幼保健院妇科,浙江嘉兴314051

出　　处：《中国现代医生》2015年第15期31-33,36,共4页China Modern Doctor

基　　金：浙江省医药卫生科技项目(2010KYB108)

摘　　要：目的研究左炔诺孕酮宫内释放系统对子宫内膜息肉患者子宫内膜组织胰岛素样生长因子-1（IGF-1）表达的影响。方法选取2010年1月~2011年12月期间行宫腔镜下子宫内膜息肉切除术182例患者为研究对象,将其随机分为对照组（常规治疗组）94例和研究组（宫内放置左炔诺孕酮宫内释放系统）88例。后通过免疫组化法将术中内膜组织及术后6个月子宫内膜活检IGF-1的表达情况进行对比,且追踪随访2年,观察患者子宫内膜息肉复发情况。结果研究组内膜组织IGF-1表达研究组术后明显低于术中,差异有统计学意义,对照组IGF-1的表达变化无差异性。随访2年对照组87例患者中7例子宫内膜息肉复发,复发率为8.05%,而研究组无一例复发,差异有统计学意义。结论左炔诺孕酮宫内释放系统可能通过抑制子宫内膜的IGF-1来降低子宫内膜息肉复发。Objective To study levonorgestrel intrauterine system on insulin-like growth factor-1 （IGF-1） in endometri- um tissue for patients with endometrial polyps. Methods All 182 patients with endometrial polyps in our hospital from January 2010 to December 2011 were selected as research object, and randomly divided into control group （routine treatment group） 94 cases and observation group（levonorgestrel intrauterine system in uterus group）88 cases. The IGF- 1 expression of endometrial biopsy specimens during intraoporativc and rechected after 6 months were measurd by im- munohistochemistry. Patients were followed up for 2 years to analyse endometrial polyp recurrence. Results The ex- pressions of IGF-1 decreased significant in endometrium tissue of observation group with operation. But there were no significant differences in control group. Followed up for 2 years, the endometrial polyp recurrence was 8.05% in control group and without recurrence in study group. Conclusion Levonorgestrel intrauterine system may be involved in the in- hibiting of the expression of IGF-1 then to induce the recurrence of endometrial polyps.

关 键 词：子宫内膜息肉 左炔诺孕酮宫内系统 胰岛素样生长因子 

分 类 号：R737.3[医药卫生—肿瘤]