肝动脉栓塞化疗联合调强放疗治疗原发性肝癌的临床疗效  

Clinical efficacy of TACE combined with three-dimensional conformal radiotherapy in treatment of HCC

作　　者：吴鹤[1] 应晓珍[1] 吕素珍[1] 鲍黎明[1] 纪建松[2] 

机构地区：[1]浙江省丽水市中心医院放疗科,浙江丽水323000 [2]浙江省丽水市中心医院放射科,浙江丽水323000

出　　处：《中国现代医生》2015年第20期51-53,57,共4页China Modern Doctor

基　　金：浙江省科技计划项目(2013C03010);浙江省丽水市科技计划项目(2012ZC025)

摘　　要：目的探讨肝动脉栓塞化疗（TACE）联合调强放疗（IMRT）治疗原发性肝细胞癌（HCC）的临床疗效。方法将我院2012年1月~2014年12月收治的HCC患者68例随机分为观察组和对照组两组,每组34例。对照组采用TACE治疗,观察组给予TACE联合IMRT治疗,观察两组患者的临床疗效。结果观察组总有效率88.64%显著高于对照组65.91%（χ^2=6.471,P=0.011）;观察组1年、2年生存率73.8%、53.2%均明显高于对照组43.6%、20.3%（P〈0.05）;观察组毒副反应发生率较对照组低,但无显著性差异（P〉0.05）。结论应用TACE联合IRGT治疗HCC可显著提高临床疗效,且不良反应少,耐受性好,安全可靠。Objective To investigate the clinical efficacy of TACE combined with IMRT in treatment of HCC. Methods All 68 cases with HCC were selected from our hospital and randomly divided into two groups according to the sequence number of admission from January 2012 to December 2014, 34 cases in each group, single number in the control group, double number in the observation group. The control group received TACE for treatment, the observation group received TACE combined with IRGT treatment, clinical efficacy of two groups were compared. Results Total efficiency of the observation group was 88.64% significantly higher than 65.91% in the control group（x^2=6.471 ,P=0.011）; 1 year, 2-year survival rate of the observation group were 73.8%, 53.2% were significantly higher than 43.6%, 20.3% in the control group（P〈0.05）;the incidence of adverse reactions of the observation group lower than the control group, but there was no significant difference （P〉0.05）. Conclusion TACE combined with 3D-CRT in treatment of HCC can sig- nificantly improve the clinical efficacy, and fewer adverse reactions, well tolerated, safe and reliable.

关 键 词：原发性肝细胞癌 肝动脉栓塞化疗 三维适形放疗 疗效 

分 类 号：R735.7[医药卫生—肿瘤]