TACE联合RFA治疗原发性肝癌中长期生存率研究  

Research on the long-term survival of primary liver cancer of TACE combined with RFA

作　　者：姚征[1] 陈玉堂[1] 陈波[2] 

机构地区：[1]浙江省肿瘤医院介入科,浙江杭州310022 [2]浙江省肿瘤医院病理科,浙江杭州310022

出　　处：《中国现代医生》2015年第22期1-4,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划(2012KYB030)

摘　　要：目的探讨TACE联合RFA对原发性肝癌对患者长期生存率的影响。方法选取2009年6月~2014年6月于我院进行治疗的100例中晚期原发性肝癌患者。按照随机数字表法将其分为射频治疗组（RFA,50例）和联合治疗组（TACE＋RFA,50例）。其中,射频治疗组患者单纯进行RFA治疗;联合治疗组患者采取RFA和TACE结合联合治疗。随访时间为12~50个月,比较两组患者的长期疗效及生存状况。结果通过分析对比两组患者治疗后远期生存状况发现,射频治疗组患者生存期为1~60个月,联合治疗组患者生存期为2~89个月。1年生存率联合治疗组显著高于射频治疗组（P〈0.05）;3年生存率联合治疗组显著高于射频治疗组（P〈0.05）;5年生存率联合治疗组显著高于射频治疗组（P〈0.05）。联合治疗组统计的各项生存指标均优于前者,差异有统计学意义（P〈0.05）。结论 TACE和RFA联合治疗方案对于原发性肺癌患者具有更好的治疗效果,在提高患者远期生存状况方面更具有选择优势,适合临床医师在治疗时优先选择使用。Objective To explore the long-term survival of primary liver cancer of TACE combined with RFA. Methods A total of 100 cases were selected from June 2009 to June 2014 in our hospital treated with advanced hepatocellular carcinoma, according to a random number table method, they were randomly divided into treatment group radiofre-quency（RFA, 50 patients）, and combined treatment group （TACE＋RFA, 50 patients）. Among them, the RF-treated patients were treated with RFA alone; the combined treatment group were taken RFA and TACE combined with combi- nation therapy. Follow-up for 12 to 50 months, the long-term efficacy and survival of the two groups of patients were compared. Results By analyzing and comparing two groups of patients after treatment, long-term survival of discovery, survival radiofrequency of treatment group was 1 to 60 months, the survival of patients combined treatment group was 2 to 89 months. 1-year survival rate of the combined treatment group was significantly higher than the radiofrequency treatment group（P〈0.05）; 3-year survival rate of the combined treatment group was significantly higher than radiofre- quency treatment group （P〈0.05）; 5-year survival rate of the combined treatment group was significantly higher than radiofrequency treatment group（P〈O.05）. The combined treatment group survival index statistics were better than the former, and the difference was statistically significant（P〈0.05）. Conclusion TACE and RFA combination therapy has a better therapeutic effect in improving long-term survival of patients on a more selective advantage for clinicians to use in the treatment of preference.

关 键 词：经导管动脉内化疗栓塞 射频消融治疗 原发性肝癌 长期 生存率 

分 类 号：R735.7[医药卫生—肿瘤]