食管鳞状细胞癌临床病理学特征与淋巴结转移的关联研究  

ASSOCIATION OF CLINICOPATHOLOGICAL FEATURES IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA WITH LYMPH NODE METASTASIS

作　　者：石劲松[1] 张晓娟 张玲染 侯素平 王林娜 孙晓玲 

机构地区：[1]河北省衡水市第二人民医院胸外科,053000 [2]衡水市人民医院病理科 [3]衡水市第四人民医院耳鼻喉科

出　　处：《中国煤炭工业医学杂志》2015年第9期1457-1459,共3页Chinese Journal of Coal Industry Medicine

基　　金：衡水市科学技术研究与发展计划项目(12017A)

摘　　要：目的探讨食管鳞状细胞癌(ESCC)的细胞分化程度、浸润深度(T分期)及肿瘤最长径等临床病理特征与淋巴结转移之间的关系。方法对2008年6月—2014年6月行手术治疗的376例ESCC患者的临床及病理资料进行了回顾性分析,比较肿瘤不同分化程度、浸润深度及不同最大径分组之间淋巴结转移情况的差异。结果随着肿瘤细胞分化程度的降低与浸润程度的加深,淋巴结转移阳性率显著升高(χ2=105.198及118.813,P<0.001),而肿瘤最长径≥3cm患者淋巴结转移率明显高于<3cm患者(χ2=88.289,P<0.001)。结论 ESCC的分化程度、浸润深度及肿瘤最长径与淋巴结阳性转移率呈正相关,在ESCC的临床分期及预后判断方面起重要作用。Objective To investigate the relationship between cell differentiation, the depth of invasion（T） and tumor length and lymph node metastasis（ N） in esophageal squamous cell carcinoma（ ESCC） patients. Methods A retrospective review of 376 consecutive patients undergone esophageal resection was conducted to define the association between histologie differentiation, T and tumor length and N. Results With the differentiation reducing and the infiltration increasing, lymph node metastasis increased significantly （χ2 = 105. 198 and 118. 813 ,P〈0. 001 ）. Lymph nodemetastasis in patients with maximum tumor diameter ≥3cm was significantly higher than that in patients 〈3em（ X2 = 88. 289,P〈0. 001）. Conclusion Cell differentia- t4on, the depth of invasion and tumor length in ESCC patients are positive correlated with lymph node me- tastasis, and play an important role in clinical staging and prognosis.

关 键 词：食管鳞状细胞癌 细胞分化 肿瘤最长径 淋巴结转移 

分 类 号：R735.1[医药卫生—肿瘤]