紫杉醇加顺铂方案与顺铂加氟尿嘧啶方案化疗同步放疗对局部晚期喉癌的效果和毒性  

EFFECTS AND TOXICITY OF PACLITAXEL PLUS CISPLATIN AND CISPLATIN PLUS FLUOROURACIL CONCURRENT CHEMORADIOTHERAPY IN THE TREATMENT OF LOCALLY ADVANCED LARYNGEAL CANCER

作　　者：汤晨[1] 郁汉旭 刘收厚[1] 王成师[2] 

机构地区：[1]南京医科大学附属淮安第一医院耳鼻喉科,江苏省淮安市223001 [2]淮安市涟水县人民医院放疗科

出　　处：《中国煤炭工业医学杂志》2015年第9期1460-1462,共3页Chinese Journal of Coal Industry Medicine

基　　金：江苏省淮安市科技支撑计划(编号:2012018)

摘　　要：目的 探讨紫杉醇加顺铂（TP）方案与顺铂加氟尿嘧啶（PF）方案化疗同步放疗对局部晚期喉癌的效果和毒性。方法 随机选取2011年3月—2014年10月南京医科大学附属淮安第一医院耳鼻喉科收治的局部晚期喉癌患者80例,依据治疗方法将这些患者分为TP组（n=40）和PF组（n=40）,给予二组患者化疗同步放疗,然后对二组患者的近期疗效、毒性反应发生情况及生存情况进行统计分析。结果 TP组患者治疗的总有效率92.5%（37/40）显著高于PF组60.0%（24/40）（P〈0.05）,Ⅲ～Ⅳ度放射性咽喉炎、胃肠道反应、骨髓抑制发生率均显著高于PF组（P〈0.05）。结论 在局部晚期喉癌的治疗中,TP方案较PF方案化疗同步放疗具有较好的效果和较小的毒性。Objective To investigate the effects and toxicity of Paclitaxel plus Cisplatin （TP） program and Cisplatin plus Fluorouracil （PF） program concurrent chemoradiotherapy in the treatment of locally ad- vanced laryngeal cancer. Methods Totally 80 cases of patients with locally advanced laryngeal cancer who were treated in authors hospital from March 2011 to October 2014 were randomly selected, they were di- vided into TP group （n = 40） and PF group （n = 40） according to the treatment methods, the patients were given concurrent chemoradiotherapy, then the short- term effect, the incidence of toxicity and survival of the two groups were analyzed. Results The total treatment efficiency of TP group 92.5% （37/40） was significantly higher than PF group 60. 0% （24/40） （P〈0.05）, the incidence of degree of Ⅲ～Ⅳ radioac- tive sore throat, gastrointestinal tract, hone marrow suppression were also significantly higher than PF group （P〈0.05）. Conelusion TP program concurrent chemoradiotherapy has better clinical efficacy and less toxicity than PF program in the treatment of locally advanced laryngeal cancer.

关 键 词：TP方案 PF方案 化疗同步放疗 局部晚期喉癌 毒性 

分 类 号：R739.65[医药卫生—肿瘤]