MDM2启动子SNP309多态性与亚洲人群乳腺癌易感性关系的Meta分析  

Meta-analysis of Correlation between MDM2 Promoter Polymorphism SNP309 and Breast Cancer Susceptibility

作　　者：魏晓东[1] 张可[1] 么坤 王燕[2] 

机构地区：[1]甘肃省人民医院急诊科,兰州730000 [2]河北省唐山市人民医院妇产科,唐山063000

出　　处：《世界科技研究与发展》2015年第4期377-380,共4页World Sci-Tech R&D

摘　　要：目的探讨MDM2基因启动子309位点多态性与亚洲人群乳腺癌易感性的关系。方法计算机检索Pub Med、EMBASE、Cochrane Library、中国期刊全文数据库、中国生物医学文献数据库、中文科技期刊数据库和万方数据库,收集MDM2基因SNP309多态性与亚洲人乳腺癌易感性关系的相关文献,然后用Stata软件进行亚组分析、敏感性分析和文献的发表偏倚检验。结果病例组和对照组相比,显性模型（GG＋TG vs TT：OR=1.012,95%CI为0.56~1.83）、隐性模型（GG vs TG＋TT：OR=1.10,95%CI为0.65~1.263）和等位基因模型（G vs T：OR=1.012,95%CI为0.81~1.83）,共显性模型（GG vs TT：OR=0.86,95%CI为0.49~1.58）,无统计学意义。结论在亚洲人群患者人群中,携带MDM2SNP309不会提高乳腺癌的发病风险。Objective To determine whether MDM2 T309G polymorphism is associated with the risk of gynecologic cancer, including Ovarian, Endometrial, Cervical and Breast. Methods The relevant published studies were retrieved from PubMed, EMBASE, Cochrane Library , China National Knowledge Infrastructure , Chinese Biomedical Literature Data, Chinese Sci- ence and Technology Periodicals Data and WanFang databases with computer, obtain all the case - control studies evaluating the association between MDM2 （ murine double minute 2） SNP309 and Asian patient~ with breast carcinoma. The statistical analysis was conducted by STATA software. Results Comparing the case group with the control group, there was statistically significant in the Dominant model （ GG ＋ TG vs TT ： OR = 1. 012 CI 0. 65 - 1.83 ） ）, the implicit model （ GG vs TG ＋ TT： OR = 1.10,95% CI 0. 65 - 1. 263） and allele model （ G vs T：OR = 1. 012, 95% C I 0. 81 - 1.83 ）, and codominant mod- el （GG vs TT：OR =0. 86 ;95% CI 0.49 - 1.58 ） codominant model, with no statistical significance. Conclusion In Asian patients with breast carcinoma, carrying MDM2SNP309 may not increase risk of breast tumors.

关 键 词：MDM2基因 SNP309 基因多态性 乳腺癌 META分析 

分 类 号：R737.9[医药卫生—肿瘤]