新疆地区胰腺癌手术患者预后相关因素分析  

Relative factors analysis on the prognosis of pancreatic cancer surgery in Xinjiang

作　　者：孙岩娜[1] 艾斯克尔.吐拉洪 张瑞丽[1] 包永星[1] 张仑[1] 张华[1] 

机构地区：[1]新疆医科大学第一附属医院肿瘤中心二科,乌鲁木齐830054

出　　处：《新疆医科大学学报》2015年第9期1155-1158,共4页Journal of Xinjiang Medical University

基　　金：乌鲁木齐市科学技术计划(Y111310043);乌鲁木齐市科学技术计划(H111313001)

摘　　要：目的探讨胰腺癌手术患者的生存状况及其预后的相关因素。方法回顾性分析新疆医科大学第一附属医院2002年1月1日-2010年12月31日收治的152例胰腺癌手术患者的临床资料,对肿瘤大小、术前糖类抗原199(CA199)水平、糖类抗原242(CA242)水平、癌胚抗原(CEA)水平、手术方式、有无淋巴结转移、有无远处转移、临床分期及有无术后治疗等分别采用Kaplan-Meier及Cox比例风险模型进行单因素及多因素分析。结果完整随访的152例腺癌患者中存活39例(25.7%),死亡113例(74.3%),中位生存时间为277d,6个月、1年、2年及3年生存率分别为68.1%、38.3%、27.7%、23.6%;单因素分析显示肿瘤大小、术前CA199水平、手术方式、有无淋巴结转移、有无远处转移、临床分期及有无术后治疗是影响胰腺癌手术患者预后因素,差异均有统计学意义(P<0.05);多因素分析显示肿瘤大小、有无淋巴结转移、有无远处转移及手术方式为影响胰腺癌手术患者的独立预后因素(P<0.05)。结论胰腺癌手术患者的肿瘤大小、有无淋巴结转移、有无远处转移及手术方式是预后的主要影响因素。Objective To explore the survival condition of patients with pancreatic cancer surgery and its re- lated factors of prognosis. Methods A retrospective analysis on 152 cases with pancreatic cancer surgery from Jan 1,2002 to Dec 31, 2010 in the First Affiliated Hospital of Xinjiang Medical University.Based on the data of tumor size preoperative carbohydrate antigen 199 （CA199）, carbohydrate antigen 242 （CA242）, carcinoembryonic antigen （CEA） levels, operation method, with and without lymph node me- tastasis, distant metastasis, clinical stage, and presence of postoperative treatment, Kaplan Meier and Cox proportional hazards models were used respectively for single factor and multiple factors analysis. Results 39 cases （25.7%） survived from complete follow-up of 152 cases of adenocarcinoma patients, 113 cases died （74.3%）, the median survival time of pancreatic cancer was 277 d, 6 months, 1 year, 2 years, re- spectively, and 3 year survival rate was 68.1%, 38.3%, 27.7% and 68.1%, respectively. Single factor a- nalysis showed that tumor size, preoperative CA199 levels, operation way, lymph node metastasis, distant metastasis, clinical stage, and presence of postoperative therapy are the factors affecting the prog- nosis of patients with pancreatic cancer surgery, the differences were statistically significant （P 〈0.05） And multi-factor analysis showed that tumor size, lymph node metastasis, presence of distant metastasis and operation types were attributed to independent prognostic factors for pancreatic cancer surgery patients（P 〈0.05）. Conclusion The main factors of tumor size, lymph node metastasis, presence of distant me- tastasis might be impacts on the prognosis and surgical type in patients with pancreatic cancer surgery.

关 键 词：胰腺癌 手术 预后 影响因素 

分 类 号：R735.9[医药卫生—肿瘤]