重复经颅磁刺激合并度洛西汀治疗抑郁症的临床研究  

Clinical Study on rTMS and duloxetine in the Treatment of Treatment-Resistant Depression

作　　者：施玉梅[1] 许小梅[1] 孙红杰[1] 靳红强[1] 郝翠杰[1] 

机构地区：[1]河北省荣军医院

出　　处：《现代养生》2015年第17期57-59,共3页Health Protection and Promotion

摘　　要：目的对重复经颅磁刺激（r TMS）合并度洛西汀治疗抑郁症进行探讨,研究其临床疗效及副作用。方法将84例抑郁症患者随机分为观察组和对照组,每组各42例,研究组给予r TMS真刺激,对照组给予r TMS假刺激,对右侧前额叶进行刺激（都给予5赫兹,连续4.9秒的刺激;每两次间隔30s,每次治疗给予10次刺激,10次一个疗程,持续28天）。合并给予度洛西汀,于治疗前及治疗28天后后应用汉密尔顿抑郁量表（HAMD）及不良反应量表（TESS）对比两组的疗效不良反应。结果观察组治疗后的HAMD评分下降明显,与假刺激组相比存在统计学差异（P〈0.05）,不良反应轻微。结论重复经颅磁刺激（r TMS）合并度洛西汀治疗抑郁症效果好,无副反应。Objective To explore the efficacy and safety of repetitive transcranial magnetic stimulation（rTMS）combining with duloxetine in the treatment of depression. Methods Thirty patients with TRD were randomly divided into a real rTMS group and a sham rTMS group,both with Mirtazapine treatment.Each patient in the real rTMS group received 20 rTMS sessions over 4 weeks to the left dorsolateral prefrontal cortex.ttamilton Depression Scale（HAMD）and treatment emergent symptom scale（TESS） were used to assess the therapeutic effect of two treatment methods at baseline and at 4 weeks after treatment. Adverse reactions were observed and recorded in a 4 weeks＇duration.Results There was significant improvement in the real rTMS group,as measured by scores on the HAMD and TESS.The difference between the real rTMS group and the sham rTMS group was significant（P〈0.05）.There was no serious adverse reaction.Conclusions As an effective and safe treatment for treatment resistant depression,repetitive transcranial magnetic stimulation（rTMS）combining with Mirtazapine has broad application prospects.

关 键 词：重复经颅磁刺激 抗抑郁药 度洛西汀 抑郁症 

分 类 号：R742.5[医药卫生—神经病学与精神病学]