Intravoxel incoherent motion magnetic resonance imaging for diagnosis of cervical cancer and evaluation of response of uterine cervical cancer to radiochemotherapy: A pilot study  

作　　者：Yanchun Wang Shan Hu Xuemei Hu Jianjun Li Yaqi Shen Xiaoyu Liu Zhi Wang Xiaoyan Meng Zhen Li Daoyu Hu 

机构地区：[1]Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology [2]Department of Radiology, Guangdong General Hospital

出　　处：《Oncology and Translational Medicine》2015年第4期164-170,共7页肿瘤学与转化医学（英文版）

基　　金：Supported by grants from the the National Natural Science Foundation of China(No.81371524,81271529);the Hubei Provincial Natural Science Foundation of China(No.2014CFB298)

摘　　要：Objective The aim of this study was to investigate the ability of intravoxel incoherent motion(IVIM) diffusion-weighted magnetic resonance imaging(MRI) to diagnose cervical cancer and to evaluate the response of uterine cervical cancer to radiochemotherapy(CRT).Methods This prospective study was approved by the institutional review board, and informed consent was obtained from all patients. A total of 23 patients with primary cervical cancer who were undergoing CRT and 16 age-matched healthy subjects were prospectively recruited for IVIM(b = 0–800 s/mm2) and standard pelvic MRI. Bi-exponential analysis was performed to derive f(perfusion fraction), D*(pseudo-diffusion coefficient), and D(true molecular diffusion coefficient) in cervical cancer(n = 23) and the normal cervix(n = 16). The apparent diffusion coefficient(standard ADC) was calculated. The independent-samples t-test and paired-samples t-test were used for comparisons.Results Pre-treatment cervical cancer had the lowest standard ADC(1.15 ± 0.13 × 10-3 mm2/s) and D(0.89 ± 0.10 × 10-3 mm2/s) values, and these were significantly different from the normal cervix and posttreatment cervical cancer(P = 0.00). The f(16.67 ± 5.85%) was lowest in pre-treatment cervical cancer and was significantly different from the normal cervix and post-treatment cervical cancer(p = 0.012 and 0.00, respectively). No difference was observed in D*.Conclusion IVIM is potentially promising for differentiating between the normal cervix and cervical cancer because pre-treated cervical cancer has low perfusion and diffusion IVIM characteristics. Further, the standard ADC, D, and f of cervical cancer showed a tendency to normalize after CRT; thus, IVIM may be useful for monitoring the response to CRT in cervical cancer.Objective The aim of this study was to investigate the ability of intravoxel incoherent motion （IVIM） diffusion-weighted magnetic resonance imaging （MRI） to diagnose cervical cancer and to evaluate the response of uterine cervical cancer to radiochemotherapy （CRT）. Methods This prospective study was approved by the institutional review board, and informed consent was obtained from all patients. A total of 23 patients with primary cervical cancer who were undergoing CRT and 16 age-matched healthy subjects were prospectively recruited for IVIM （b = 0-800 s/mm^2） and stan- dard pelvic MRI. Bi-exponential analysis was performed to derive f （perfusion fraction）, D＊ （pseudo-diffusion coefficient）, and D （true molecular diffusion coefficient） in cervical cancer （n = 23） and the normal cervix （n = 16）. The apparent diffusion coefficient （standard ADC） was calculated. The independent-samples t-test and paired-samples t-test were used for comparisons. Results Pre-treatment cervical cancer had the lowest standard ADC （1.15 ± 0.13 × 10^-3 mm^2/s） and D （0.89 ± 0.10× 10^-3 mm^2/s） values, and these were significantly different from the normal cervix and post- treatment cervical cancer （P = 0.00）. The f （16.67 ± 5.85%） was lowest in pre-treatment cervical cancer and was significantly different from the normal cervix and post-treatment cervical cancer （p = 0.012 and 0.00, respectively）. No difference was observed in D＊. Conclusion IVIM is potentially promising for differentiating between the normal cervix and cervical can- cer because pre-treated cervical cancer has low perfusion and diffusion IVIM characteristics. Further, the standard ADC, D, and f of cervical cancer showed a tendency to normalize after CRT; thus, IVIM may be useful for monitoring the response to CRT in cervical cancer.

关 键 词：diffusion-weighted imaging magnetic resonance imaging （MRI） investigate the ability of intravoxel incoherent motion （IVIM） cervical cancer RADIOCHEMOTHERAPY 

分 类 号：R737.33[医药卫生—肿瘤] R445.2[医药卫生—临床医学]