Skp2,p27在眼附属器黏膜相关淋巴组织结外边缘区B细胞淋巴瘤中的表达和意义（英文）  

The expression and meaning of Skp2,p27 proteins in Mucosa-associated lymphoid tissue lymphoma of ocular adnexal

作　　者：林红[1] 胡丽婷[1] 赵桂秋[1] 杨文毅[1] 张静静[1] 

机构地区：[1]青岛大学附属医院眼科,中国山东省青岛市266003

出　　处：《国际眼科杂志》2015年第9期1489-1493,共5页International Eye Science

基　　金：Supported by Public Domain of Science and Technology Project of Qingdao(No.2012-1-3-2-14-nsh)~~

摘　　要：目的：探讨眼附属器黏膜相关淋巴组织结外边缘区B细胞淋巴瘤（mucosa-associated lymphoid tissue lymphoma of ocular adnexal,MALT lymphoma of ocular adnexal）中Skp2和p27的表达及联系。方法：收集1995-2011年青岛大学附属医院眼科切除的眼附属器MALT淋巴瘤患者及眼部反应性淋巴组织增生患者的石蜡包埋标本,用免疫组化法分别检测两组标本中Skp2和p27的表达。结果：眼附属器MALT淋巴瘤中Skp2表达率与眼部反应性淋巴组织增生相比显著增高（P〈0.05）。p27表达率与反应性淋巴组织增生相比显著降低（P〈0.05）。Skp2和p27的表达与患者Ann Arbor病理分级无关。在眼附属器MALT淋巴瘤中Skp2与p27成负相关（r=-0.129,χ2=15.39,P〈0.05）。结论：综合分析眼附属器MALT淋巴瘤中P27及SKP2的表达对本病的预后有一定意义。两者的表达彼此相关。AIM： To investigate the expression and relationship of S- phase kinase-associated protein 2 （Skp2） and p27 in mucosa-associated lymphoid tissue （MALT） lymphoma of ocular adnexal. METHODS：The expression of Skp2, p27 were detected on resected specimens from patients suffering from MALT lymphoma and lymphadenosis of ocular adnexal in Ophthalmology Department, Affiliated Hospital of Medical College Qingdao University from 1995 to 2011 by immunohistochemical analysis. RESULTS： The expression of Skp2 in MALT lymphoma was higher than that in lymphadenosis （ P〈 0.05）. The expression of p27 in MALT lymphoma was lower than that in lymphadenosis （P〈0.05）. The expression of Skp2 and p27 do not related with the Ann Arbor clinical stage. There was a negative correlation between p27 and Skp2 in MALT lymphoma （ r= -0. 129 ,X2 = 15.39, P〈0.05）. CONCLUSION： Comprehensive analysis of the expression of p27 and Skp2 protein may have certain guiding significance on the prognosis evaluation of the disease. The expression of two substances may correlate with each other.

关 键 词：粘膜相关淋巴组织淋巴瘤 眼附属器 SKP2 P27 

分 类 号：R739.7[医药卫生—肿瘤]