IL-12p40、IL-12p70在经典型霍奇金淋巴瘤中的表达及意义  

Expression and significance of IL-12p40 and IL-12p70 in classical Hodgkin lymphoma

作　　者：陈聪[1,2] 刘芳[3] 张聪[1,2] 陈顺华[1,2] 曹立宇[1,2] 尹玉[1,2] 

机构地区：[1]安徽医科大学病理学教研室,合肥230032 [2]安徽医科大学第一附属医院病理科,合肥230022 [3]佛山科学技术学院医学院生理病生教研室,佛山528000

出　　处：《安徽医科大学学报》2015年第9期1308-1312,共5页Acta Universitatis Medicinalis Anhui

基　　金：安徽高校省级自然科学研究项目(编号:KJ2013A150)

摘　　要：目的探讨白细胞介素-12p40(IL-12p40)、白细胞介素-12p70(IL-12p70)在经典型霍奇金淋巴瘤(CHL)组织中的表达及意义。方法应用免疫组织化学法检测IL-12p40、IL-12p70在41例CHL组织、92例弥漫性大B细胞淋巴瘤(DLBCL)组织及20例反应性淋巴组织增生(RLH)中的表达。结果 IL-12p40、IL-12p70在41例CHL及92例DLBCL中的阳性表达率分别是51.22%、70.73%及0.00%、4.35%,20例RLH中未见IL-12p40及IL-12p70表达。IL-12p40、IL-12p70在CHL中及各亚型中的表达均明显高于DLBCL及RLH(P<0.05)。IL-12p40及IL-12p70的表达与患者性别、年龄、肿块大小、B症状、临床分期、血清乳酸脱氢酶水平、国际预后评分等临床病理因素均无关。IL-12p40与IL-12p70在CHL中的表达有相关性(P<0.05)。结论 IL-12p40、IL-12p70在CHL发病中有重要作用。Objective To investigate the expression and clinical significance of interleukin-12p40（IL-12p40） and interleukin-12p70（IL-12p70） in patients with classical Hodgkin lymphoma （CHL）. Methods IL-12p40 and IL- 12p70 were stained by immunohistochemical EnVision two-step method in 41 cases of CHL, 92 cases of DLBCL and 20 cases of reactive lymphoid hyperplasia （RLH）. Results The positive rates of IL-12p40 and IL-12p70 were 51.22%, 70. 73% in CHL and 0. 00% , 4. 35% in DLBCL, no expression of IL-12 was observed in RLH, The ex- pression rates of IL-12p40 and IL-12p70 in CHL were significantly higher than that in DLBCL and RLH （P 〈 0. 05）. There was no significant correlation between IL-12pd0 and IL-12p70 with sex, age, bulky disease, B symptom, clinic stage, serum LDH level, and international prognostic score. IL-12p40 was positively correlated with the expression of IL-12p70 in CHL（P 〈 0. 05）. Conclusion The IL-12p40 and IL-12p70 play important roles in the pathogenesis of CHL.

关 键 词：霍奇金淋巴瘤 弥漫性大B细胞淋巴瘤 IL-12P40 IL-12p70 免疫组织化学 

分 类 号：R733.4[医药卫生—肿瘤]