克罗恩病患者血浆中细胞间黏附分子-1和血管细胞黏附分子-1水平检测的临床意义  

Clinical significance of plasma levels of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 in Crohn's disease

作　　者：杜军[1,2] 赵孝文[1] 胡翠[1] 梅俏[1] 许建明[1] 

机构地区：[1]安徽医科大学第一附属医院消化内科、安徽省消化病重点实验室,合肥230022 [2]安徽医科大学附属六安医院消化内科,六安237005

出　　处：《安徽医科大学学报》2015年第9期1357-1359,共3页Acta Universitatis Medicinalis Anhui

基　　金：安徽省自然科学基金(编号:1308085MH146);杨森科学研究委员会中国分会研究基金(编号:JRCC2012消化02)

摘　　要：检测96例克罗恩病(CD)患者和48例正常对照者血浆细胞黏附分子-1(ICAM-1)和血管细胞黏附分子(VCAM-1)水平,与对照组比较,CD组血浆中ICAM-1和VCAM-1水平均明显增高(P<0.01)。按疾病严重程度分组,各组血浆中ICAM-1和VCAM-1水平比较差异均有统计学意义(P<0.01);按临床特征分组,各组内血浆中ICAM-1和VCAM-1水平比较差异均无统计学意义。CD患者血浆中ICAM-1和VCAM-1水平明显增高,与疾病严重程度有一定关联,与临床特征无明显关联。To evaluate the value of plasma levels of intercellular cell adhesion molecule-1 （ ICAM-1 ） and vascular cell adhesion molecule-1 （ VCAM-1 ） in Crohn＇ s diseases （CD） patients （ n = 96） and control group （ n = 48 ）. The results showed that plasma levels of ICAM-1 and VCAM-1 in the control group were lower than that in CD group significantly（P 〈0.01）. Plasma ICAM-1 and VCAM-1 concentrations of each group in active stage were signifi- cantly different between the groups （P 〈0.01 ）. CD patients were grouped according to the patient＇s age and the disease extent and the disease clinical type, within group variable, plasma levels of ICAM-1 and VCAM-1 were not significantly different. ICAM-1 and VCAM-1 mediated the intestinal inflammatory processes in the pathogenesis of CD. Plasma ICAM-1 and VCAM-1 levels may be positively associated with disease classification and are not corre- lated with the patient＇s age and the disease extent and the disease clinical type.

关 键 词：克罗恩病 细胞间黏附分子 血管间黏附分子 

分 类 号：R574[医药卫生—消化系统]