不同程度神经功能缺损的脑梗死患者血尿酸与预后的相关性研究  

The relationship between serum uric acid and prognosis of the patients with acute cerebral infarction with different degrees of neurological impairment

作　　者：史秀丽[1] 代瑞宁 刘洋[1] 傅佳[1] 

机构地区：[1]安徽医科大学第一附属医院神经内科,合肥230022

出　　处：《安徽医科大学学报》2015年第9期1360-1362,共3页Acta Universitatis Medicinalis Anhui

基　　金：安徽省卫生厅医学科研课题(编号:09A046)

摘　　要：根据美国国立卫生研究院卒中量表(NIHSS)评分将急性脑梗死患者分为轻度和中重度神经功能缺损两组,发病后第7天行NIHSS评分,第1个月和第3个月行改良RANKIN量表(mRS)评分,检测发病24 h内和发病后第7天的血尿酸(SUA)浓度,分析SUA与神经功能评分的相关性。55例轻度神经功能缺损患者的SUA浓度无明显变化,SUA浓度与评分均无关;65例中重度神经功能缺损患者的SUA浓度显著降低,且SUA变化值与第7天NIHSS和第1个月mRS有关,Logistic回归显示SUA变化值是第1个月预后不良的危险因素。According to the scores of the United States National Institutes of Health Stroke Scale （ NIHSS）, the pa- tients with acute cerebral infarction were divided into two groups with mild or moderate-severe neurological impair- ment. The NIHSS was completed in day7 and the modified RANKIN scale （mRS） was done in month 1 and month 3 after onset of stroke. The concentrations of serum uric acie （SUA） were measured within 24 hours and day 7 after onset of stroke. The correlation between SUA and neurological scores was analyzed. Of the 55 patients with mild neurological impairment, no significant changes of SUA occurred and SUA concentrations were not related to neuro- logical scores. Of the 65 cases with moderate-severe impairment, the concentrations of SUA decreased significantly and the changes of SUA were correlated with the NIHSS in day7 and the mRS in month 1. Logistic regression analy- sis showed that the change of SUA was the risk factor of poor prognosis in month 1.

关 键 词：急性脑梗死 血尿酸 预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]