胃肠胰神经内分泌肿瘤患者99Tcm-HYNIC-TOCSPECT与68Ga-DOTA-TATEPET／CT显像的对比研究  

An intrapatient comparison of 99Tcm-HYNIC-TOC imaging and 68Ga-DOTA-TATE imaging on pa- tients with gastroenteropancreatic neuroendocrine neoplasms

作　　者：于江媛[1] 李洁[2] 李囡[1] 朱华[1] 林保和[1] 范洋[1] 陈菩云 赵伟[1] 张岩[1] 翟士祯 陆明[2] 杨志[1] 

机构地区：[1]恶性肿瘤发病机制及转化研究教育部重点实验室、北京大学肿瘤医院暨北京市肿瘤防治研究所核医学科,100142 [2]恶性肿瘤发病机制及转化研究教育部重点实验室消化肿瘤内科

出　　处：《中华核医学与分子影像杂志》2015年第4期289-292,共4页Chinese Journal of Nuclear Medicine and Molecular Imaging

摘　　要：【摘要】目的通过分析胃肠胰神经内分泌肿瘤（GEP—NEN）患者99Tcm-HYNIC—TOCSPECT与68Ga-DOTA-TATEPET／CT显像结果，评估2种生长抑素受体（SSTR）显像方法的临床应用价值。方法回顾性分析2013年5月至2014年2月于北京大学肿瘤医院行99Tcm-HYNIC-TOCSPECT和68Ga-DOTA．TATEPET／CT显像的34例GEP．NEN患者资料，患者均经病理学证实。其中男17例，女17例，年龄23275岁。对比分析其显像结果，配对资料的比较采用疋。检验，两样本均数的比较采用两样本t检验。结果99Tcm-HYNIC-TOC显像阳性率为58．8％（20／34），68Ga-DOTA-TATE显像阳性率为70．6％（24／34），二者比较差异无统计学意义（χ2=2．25，P〉0．05）。而以受累系统为对象，2种显像方法检出率之间的差异具有统计学意义[9．5％（29／306）和15．7％（48／306）;χ2=17．50，P〈0．05]，且差异主要表现在淋巴结、肝、骨等脏器。就肝脏病灶而言，99Tcm-HYNIC-TOC显像阳性和阴性病灶的短径和SUVmax比较，差异均具有统计学意义（t=4．4和3．2，均P〈0．05）。结论 68Ga—DOTA—TATEPET／CT显像在探测小病灶及解剖结构相对复杂的病灶方面具有优势。Objective To compare the diagnostic performances of 99Tcm-HYNIC-TOC SPECT and 6SGa-DOTA-TATE PET/CT on＇patients with gastroenteropancreatic neuroendocrine neoplasm （GEP-NEN）. Methods From May 2013 tolFebruary 2014, 34 patients （ 17 males, 17 females; age： 23-75 years） with histologically proven GEP-NEN were enrolled in the study. All patients underwent 99Tcm-HYNIC-TOC SPECT imaging and 6SGa-DOTA-TATE PET/CT imaging. χ2 test and two-sample t test were used to analyze the data. Results The positive rate of 99Tcm-HYNIC-TOC imaging was 58.8% （20/34）, which had no sta- tistical difference with that of 6s Ga-DOTA-TATE imaging （ 70.6%, 24/34; χ2 = 2.25, P〉 0.05 ）. However, taking lesions as the target, the detection positive rate of 6SGa-DOTA-TATE imaging （ 15.7%, 48/306） was statistically higher than that of 99Tcm.HYNIC.TOC imaging （ 9.5%, 29/306; χ2 = 17.50, P〈 0.05 ）, espe- cially for the lymph nodes, liver and skeleton lesions. For the liver lesions, the short diameter and SUVmax of 99Tc-HYNIC-TOC positive lesions in the liver were statistically higher than those of negative lesions （ t =4.4 and 3.2, both P〈0.05）. Conclusion Compared with 99Tcm-HYNIC-TOC scintigraphy, 6SGa-DOTA- TATE PET/CT imaging shows a significantly higher detection rate on small or structure-complex lesions on GEP-NEN patients.

关 键 词：神经内分泌瘤 体层摄影术 发射型计算机 单光子体层摄影术 发射型计算机体层摄影术 X线计算机 锝 镓放射性同位素 HYNIC—TOC DOTA—TATE 

分 类 号：R735[医药卫生—肿瘤] R730.44[医药卫生—临床医学]