热疗联合同步放化疗对中晚期食管癌的临床疗效及其对血清血管内皮生长因子的影响  

Clinical efficacy of hyperthermia combined with concurrent chemoradiotherapy on the treatment of advanced esophageal cancer and its effect on serum vascular endothelial growth factor

作　　者：吕江 寿文祥 李瑞莹[2] 朱伟良[3] 

机构地区：[1]诸暨市第六人民医院内科,浙江诸暨311801 [2]广东药学院附属第一医院检验科,广州510080 [3]南方医科大学附属第二医院肿瘤中心,广州510282

出　　处：《中国临床药理学杂志》2015年第16期1600-1602,共3页The Chinese Journal of Clinical Pharmacology

基　　金：广东省医学科研基金(2014年)资助项目(A2014364)

摘　　要：目的探讨热疗联合多西紫杉醇＋卡铂同期放疗对中晚期食管癌的临床疗效及其对血清血管内皮生长因子的影响。方法将50例中晚期食管癌患者随机分为对照组25例和试验组25例。对照组予以静脉滴注75 mg·m^-2多西紫杉醇,1 h,第1天＋静脉滴注25 mg·m^-2卡铂,第1-3天;试验组在对照组的基础上,同期用NRL-004肿瘤热疗系统进行热疗,热疗输出功率900-1200 W,每周两次。2组患者一个周期均为28 d,均接受两个周期治疗。比较2组患者的近期临床疗效、治疗前后的血清血管内皮生长因子水平和生存质量评分以及不良反应发生率。结果治疗后,试验组总有效率84.00%显著高于对照组68.00%（P〈0.05）。治疗后,试验组血清血管内皮生长因子水平显著下降,对照组血清血管内皮生长因子水平有略微下降,且试验组显著低于对照组（P〈0.05）。治疗后,试验组生存质量评分（54.32±9.42）显著高于对照组（42.04±10.51）（P〈0.05）。试验组的主要不良反应为恶心呕吐和脱发,发生率分别为48.00%和56.00%;对照组的主要不良反应为恶心呕吐和脱发,发生率分别为52.00%和64.00%,2组比较差异有统计学意义（P〈0.05）。结论热疗联合多西紫杉醇＋卡铂同期放疗治疗中晚期食管癌的近期临床疗效显著,能有效地降低血清血管内皮生长因子水平,而且不良反应较少,值得在临床中推荐。Objective To evaluate the clinical efficacy of docetaxel ＋carboplatin combined with hyperthermia on treatment of advanced esophageal cancer and its effect on serum vascular endothelial growth factor（ VEGF）. Methods Fifty patients with advanced esophageal cancer were randomly divided into treatment group（ n = 25） and control group（ n = 25）.Control group was treated with docetaxel,intravenous 75 mg ·m^- 2,1 h,day 1 ＋ carboplatin,intravenous infusion 25 mg · m^- 2,day 1- 3. A period of 28 days,a total of two treatment cycles. Treatment group was treated with docetaxel, intravenous 75 mg · m^- 2,1 h,day 1 ＋carboplatin,intravenous infusion 25 mg · m^- 2,day 1- 3,combined with the same period of hyperthermia,NRL- 004 tumor hyperthermia system,heat output power 900- 1200 W,twice a week,a period of 28 days,a total of two treatment cycles. Short- term clinical efficacy,serum VEGF levels and quality of life scores and the incidence of adversedrug reactions were compared between the two groups. Results After treatment,the total efficacy of 84. 00% in treatment group was significantly higher than that in control group（ 68. 00%,P〈0. 05）,serum VEGF levels in treatment group were significantly decreased than that in control group（ P〈0. 05） which had a slight decrease. Quality of life score of patients in treatment group（ 54. 32 ± 9. 42） was significantly higher than that in control group（ 42. 04 ± 10. 51,P〈0. 05）. The main adverse drug reactions in treatment group were nausea and vomiting（ 48. 00%）,hair loss（ 56. 00%） and in control group they were 52. 00% and 64. 00%,respectively. There were of significant differences between the two groups（ P〈0. 05）. Conclusion Docetaxel ＋ carboplatin combined with hyperthermia on the treatment of patients with advanced esophageal cancer had more significant short- term effect,and it can effectively reduce serum VEGF levels and fewer adverse drug reactions. It is recommended to be widely adpoted in clinic.

关 键 词：热疗 放化疗 中晚期食管癌 血清血管内皮生长因子 临床疗效 

分 类 号：R735.1[医药卫生—肿瘤] R979.1[医药卫生—临床医学]