紫杉醇脂质纳米粒子对KB、SKOV3细胞作用的对比分析  

Comparison and Analysis of the Affection of TAX-NLC on KB,SKOV3 Cells

作　　者：王宗站[1] 杨金霞[1] 周宓[1] 邢晓波[1] 

机构地区：[1]山东省青岛市肿瘤医院,山东青岛266042

出　　处：《中国医学创新》2015年第24期1-4,共4页Medical Innovation of China

摘　　要：目的:比较紫杉醇脂质纳米粒子(TAX-NLC)对KB、SKOV3细胞的抑制作用。方法:激光共聚焦显微镜观察TAX-NLC作用于KB、SKOV3细胞对Ca2+的影响;MTT法测定TAX-NLC作用于KB、SKOV3细胞抑制率;激光共聚焦显微镜观察TAX-NLC作用于KB、SKOV3细胞形态学的变化。结果:TAX-NLC作用后KB细胞Ca2+浓度高于SKOV3细胞;TAX-NLC作用后KB细胞的抑制率高于SKOV3细胞;TAX-NLC作用KB细胞产生多核细胞高于SKOV3。结论:TAX-NLC对KB细胞更敏感,Ca2+浓度、抑制率、多核细胞比例密切相关联。Objective： To compare the inhibitory effect of paclitaxel lipid nanoparticles （ TAX-NLC ） on KB, SKOV3 cells. Method： The affection of TAX-NLC on Ca2＋ in KB, SKOV3 cells by using Laser confocal microscope were observed.MTT method was used to determine the inhibition rate of TAX - NLC action in KB, SKOV3 cell.The cell morphological changes of TAX - NLC role in KB, SKOV3 cells were observed by Laser confocal microscope.Result： After the TAX-NLC acting on KB, SKOV3 ceils, the concentration of Ca2＋ of KB cells was higher than that of SKOV3 cells.And the inhibition rate of KB cell was higher than that of SKOV3 cells, the production of KB muhinucleated ceils was more than that of SKOV3 cells.Conclusion： TAX-NLC is more sensitive to KB cells, Ca2＋ concentration, the inhibition rate, muhinucl ated ceils are closely associated.

关 键 词：紫杉醇纳米粒子 紫杉醇 CA2+ 多核细胞 

分 类 号：R73-3[医药卫生—肿瘤]