Galectin-3和E-cadherin在胃腺癌组织中的表达及与血管生成的关系  

Expression of Galectin-3 and E-cadherin in gastric adenocarcinoma tissue: Relationship with angiogenesis

作　　者：王世超[1] 张自森[2] 夏兴洲[1] 兰海涛[1] 刘谦[1] 吴诗文 薛长年[2] 

机构地区：[1]郑州大学第五附属医院消化内科,河南省郑州市450052 [2]郑州大学第五附属医院肿瘤科,河南省郑州市450052

出　　处：《世界华人消化杂志》2015年第21期3361-3365,共5页World Chinese Journal of Digestology

基　　金：河南省科技发展计划基金资助项目;No.122102310245;河南省医学科技攻关计划基金资助项目;No.201203055;河南省高等学校重点科研项目计划基金资助项目;No.15A320088~~

摘　　要：目的:探讨半乳凝集素-3(Galectin-3)和上皮钙黏附蛋白(E-cadherin)在胃腺癌组织中表达及其与微血管密度(microvascular density,MVD)的关系.方法:采用免疫组织化学方法检测60例胃腺癌组织中Galectin-3、E-cadherin和CD105蛋白的表达,分析Galectin-3、E-cadherin蛋白表达与临床病理特征、MVD的关系及二者表达的相关性.结果:胃腺癌组织中Galectin-3、E-cadherin蛋白阳性表达率分别为78.3%和63.3%,两者阳性表达呈负相关(P=0.01).Galectin-3蛋白表达与组织浸润深度有关(P=0.01),E-c a d h e r i n蛋白表达与淋巴结转移有关(P=0.01).Galectin-3蛋白阳性表达组织中MVD显著高于阴性表达组织(25.64±8.81vs 20.28±6.66,P<0.05),E-cadherin蛋白阳性表达组织中MVD显著低于阴性表达组织(22.57±7.18 vs 27.78±10.03,P<0.05).结论:胃癌组织中Galectin-3、E-cadherin蛋白表达呈负相关,可能共同影响肿瘤血管生成参与胃癌发展及转移过程.AIM： To investigate the expression of Galectin-3 and E-cadherin in gastric adenocarcinoma and their relationship with microvascular density （MVD）. METHODS： Immunohistochemistry was used to detect the expression of Galectin-3, E-cadherin and CD105 in gastric adenocarcinoma tissues. The relationship of Galectin-3 and E-cadherin expression with clinicopathological features, and the correlation between their expression were analyzed statistically. RESULTS： Galectin-3 and E-cadherin proteins were expressed positively in 78.3% and 63.3% of gastric adenocarcinoma tissues, respectively, and there was a negative correlation between Galectin-3 and E-cadherin expression （P = 0.01）. Galectin-3 expression was significantly associated with tumor invasion depth. E-cadherin expression was significantly associated with lymph node metastasis. MVD in the Galectin-3 positive group was significantly higher than that in the Galectin-3 negative group （25.64 ± 8.81 vs 20.28 ± 6.66, P 〈 0.05）. MVD in the E-cadherin positive group was significantly lower than that in the E-cadherin negative group （22.57 ±7.18 vs 27.78± 10.03, P 〈 0.05）. CONCLUSION： Galectin-3 and E-cadherin expression has a negative correlation in gastricGalectin-3 and E-cadherin may participate in the development and metastasis of gastric cancer through regulating tumor angiogenesis.

关 键 词：胃腺癌 半乳凝集素-3 上皮钙黏附蛋白 血管生成 

分 类 号：R735.2[医药卫生—肿瘤]