复方聚乙二醇与甘露醇法行结肠镜检前肠道准备的有效性及安全性Meta分析  

Meta-analysis of effectiveness and safety of polyethylene glycol vs mannitol for colonoscopy preparation

作　　者：胡洋洋[1] 凤辉[1] 王少峰[1] 

机构地区：[1]苏州大学附属第二医院消化科,江苏省苏州市215004

出　　处：《世界华人消化杂志》2015年第21期3469-3475,共7页World Chinese Journal of Digestology

摘　　要：目的:系统评价复方聚乙二醇(polyethylene glycol,PEG)和甘露醇在结肠镜检查前行肠道准备的有效性和安全性.方法:检索Medline、PubMed、EMBASE、中国生物医学文献数据库和中国期刊全文数据库中检索,收集与PEG和甘露醇行结肠镜检查前肠道准备相关的随机对照研究,根据纳入和排除标准选取文献,提取资料并评价纳入研究的质量.采用Stata12软件进行Meta分析.结果:共纳入文献15篇,共计患者3131例.Meta分析结果显示:在全结肠清洁质量优良率方面,PEG优于甘露醇溶液(RR=1.08,95%CI:1.05-1.12,P=0.000).在全结肠清洁质量优等率方面,PEG同样优于甘露醇溶液(RR=1.23,95%CI:1.09-1.39,P=0.001).在不良反应方面,PEG组在腹痛腹胀(RR=0.29,95%CI:0.22-0.39,P=0.000)、恶心呕吐(RR=0.32,95%CI:0.20-0.50,P=0.000)、饥饿头昏乏力(RR=0.25,95%CI:0.12-0.50,P=0.000)方面的发生率均明显低于甘露醇组.结论:与甘露醇相比,PEG是一种更加安全有效的肠道准备药物,但仍需更多高质量的随机对照研究加以验证.AIM： To assess systematically the effectiveness and safety of polyethylene glycol （PEG） vs mannitol for colonoscopy preparation. METHODS： Medline, PubMed, EMBASE, China Biology Medicine disc and China Journal Full-text Database were searched for randomized controlled trials that evaluated the effectiveness and safety of PEG and mannitol for colonoscopy preparation. According to the inclusion and exclusion criteria, the studies were determined. The quality of the included studies was evaluated, and Meta-analysis was performed using Stata12 software. RESULTS： A total of 15 studies involving 3131 cases were included. Meta-analysis showed that the PEG group had a higher rate of adequate cleaning quality （RR = 1.08, 95%CI： 1.05-1.12, P = 0.000） of all colon segments than the mannitol group, and the rate of excellent cleansing quality （RR = 1.23, 95%CI： 1.09-1.39, P = 0.001） in the PEG group was also superior to that in the marmitol group. The PEG group was associated with significantly lower incidences of cramps and bloating （RR =0.29, 95%Ch 0.22-0.39, P = 0.000）, nausea and emesis （RR = 0.32, 95%CI： 0.20-0.50, P = 0.000）, as well as hunger, dizziness and fatigue （RR = 0.25, 95%CI： 0.12-0.50, P = 0.000） than the mannitol group. CONCLUSION： Polyethylene glycol is superior to mannitol in terms of effectiveness and safety for colonoscopy preparation, however, more high-quality randomized controlled trials are needed to confirm our finding.

关 键 词：复方聚乙二醇 甘露醇 结肠镜检 META分析 

分 类 号：R574[医药卫生—消化系统]