Survivin与p53及Ki67蛋白在喉癌组织中的表达及相关性  

Expressions and correlations of Survivin,Ki67 and p53 in laryngeal squmous cell carcinoma

作　　者：王菊香[1] 杨宝良[2] 裴士庚[2] 王雪凌[2] 张庆军[2] 瞿峰[2] 张虹 

机构地区：[1]河北工程大学医学院,河北邯郸056002 [2]河北工程大学附属医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉头颈外科杂志》2015年第17期1545-1548,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：邯郸市科技局资助课题(No:1323108088)

摘　　要：目的:探讨Survivin、p53、Ki67在喉癌组织中的表达及三者之间的相互关系。方法:应用免疫组织化学(SP法)检侧64例喉癌组织、26例喉癌前病变组织、34例声带息肉组织中Survivin、p53、Ki67的表达情况。结果:Survivin、p53、Ki67在喉癌组织中的阳性表达率分别是59.4%、68.8%和65.6%,在喉癌前病变组织中的阳性表达率分别是15.4%、23.1%和15.4%,在声带息肉组织中的阳性表达率分别是0、8.8%、5.9%,三者均差异有统计学意义(均P<0.01)。Survivin、p53和Ki67在喉癌组织中的表达与患者年龄、病理分级及3年、5年生存无关(P>0.05),TNM分期组间存在差异(P<0.05)。Survivin、Ki67、p53在喉癌组织中的表达呈正相关(r=0.607、0.541和0.648,均P<0.01)。结论:Survivin、p53、Ki67对喉癌的发生和发展起重要作用,在喉癌的发展中起协同作用。Objective：To investigate the expression of Survivin,p53 and Ki67 in laryngeal carcinoma and the relation with clinical data. Method：Immunohistochemical staining （SP） was used to detect expression of Survivin, p53 and Ki67 of 64 cases with laryngeal carcinoma, 26 cases with precancerosis, 34 cases with vocal polyps. Result.. The positive expression rates of Survivin, p53 and Ki67 were 59.4%, 68.8%, 65.6% respectively in la- ryngeal carcinoma, which were significantly higher than those in precancerosis and vocal polyps （P〈0.01）. The expression of Survivin, p53 and Ki67 in laryngeal carcinoma were significantly statistical different in TNM stage and lymph node metastasis （P〈0.05）, but were not correlated with patientsr ages, the pathological grades, 3 years and 5 years surviving rates（P〉0.05）. The expression of Survivin, Ki-67 and p53 was positively correlated （r=0. 607, 0. 541, 0. 648, P〈0.01） in laryngeal carcinoma. Conclusion：Survivin, p53 and Ki-67 may play an im- portant role in the carcinogenesis and progress of laryngeal carcinoma. They may play synergetic roles in the process of carcinogenesis of laryngeal carcinoma.

关 键 词：喉鳞状细胞癌 免疫组织化学 生存素 P53 增殖细胞核抗原 

分 类 号：R739.6[医药卫生—肿瘤]