老年反流性食管炎患者血清Ghrelin和Leptin水平及在胃黏膜中表达的意义  

Serum levels and tissue expression of ghrelin and leptin in elderly patients with reflux esophagitis

作　　者：吴旻[1] 戴一扬[1] 厉朝喜[1] 彭芳[1] 陈凌燕[1] 翁秀妹[1] 

机构地区：[1]浙江医院消化内科,浙江杭州310013

出　　处：《中国现代医生》2015年第24期21-24,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2012KYA002)

摘　　要：目的探讨老年反流性食管炎患者生长激素释放多肽(Ghrelin)和瘦素(Leptin)血清水平及其在胃黏膜中表达的意义。方法选取老年反流性食管炎患者30例及正常对照组30例,采用ELISA法检测血清Ghrelin和Leptin水平,同时用免疫组化法检测胃黏膜中Ghrelin及Leptin的表达。结果老年反流性食管炎血清Ghrelin水平低于对照组,差异有统计学意义(P<0.05);血清Leptin水平高于对照组,差异有统计学意义(P<0.05);老年反流性食管炎胃黏膜Ghrelin表达阳性率(47%)显著低于正常对照组(76%),差异有统计学意义(P<0.05)。胃黏膜Leptin表达阳性率(83%)显著高于正常对照组(50%),差异有统计学意义(P<0.05)。老年反流性食管炎患者血清Leptin水平与Ghrelin水平呈负相关(P<0.05)。结论 Ghrelin、Leptin水平可能与老年反流性食管炎的发病有关,两者在反流性食管炎的发病中相互影响,生物学作用相反。Objective To investgate the serum level of ghrelin and leptin in the elderly patients with reflux esophagItis and gastric mucosal. Methods A total of 30 elderly patients with reflux esophagitis and 30 of healthy control cases were selected, serum ghrelin and leptin were tested by ELISA and expression of ghrelin and leptin were decteted by im- munohistochemistry. Results The serum level of ghrelin in the reflux esophagitis group was significantly lower than in the control group, the difference was significant（P〈0.05）. The serum level of leptin in reflux esophagitis group was sig nificantly higher than in the control group,the difference was significant（P〈0.05）. The expression positive rates of ghre- lin in reflux esophagitis group（47%） were significant lower than in the control group（76%）,the difference was signifi- cant（P〈0.05）. The expression positive rates of leptin in reflux esophagitis group （83%） were significant higher than the control group （50%）, the difference was significant （P〈0.05）. There were negative correlation between the serum level of leptin and the serum level of ghrelin in patients with reflux esophagitis. Conclusion The level of ghrelin and leptin may be related to pathogenesis of reflux esophagitis. It is showed that the ghrelin and leptin may have opposite effect on each other in the pathogenesis of reflux esophagitis.

关 键 词：反流性食管炎 生长激素释放多肽 瘦素 

分 类 号：R571[医药卫生—消化系统]