大剂量复方嗜酸乳杆菌治疗轻型肝性脑病的临床研究  

Clinica study of large dose compound eosinophil-lactobacillus in treat-ment of mild hepatic encephalophathy

作　　者：杨齐华[1] 胡爱荣[2] 叶国良[1] 王伯军[1] 秦丽君[1] 

机构地区：[1]宁波大学医学院附属医院消化内科,浙江宁波315000 [2]宁波市第二医院肝病科,浙江宁波315010

出　　处：《中国现代医生》2015年第24期101-104,共4页China Modern Doctor

基　　金：吴阶平医学基金会肝病医学部2011-2012年度肝功能评价方法研究基金(LDWMF-PJ-2011A003)

摘　　要：目的观察大剂量复方嗜酸乳杆菌治疗轻型肝性脑病的临床疗效。方法选择2012年1月～2014年1月在宁波大学医学院附属医院住院患者60例。将其随机分为治疗组（30例）和对照组（30例），两组均予护肝及促进氨的代谢等对症处理，对照组同时服用常规剂量复方乳嗜酸杆菌片，2片／次，3次／d，连用2周。治疗组同时服用大剂量复方乳嗜酸杆菌片5片，次，3次／d，连用2周，观察两组患者临床症状改善情况、血氨变化，肝功能改善情况及数字连线试验。划线试验时间。结果①治疗组患者神志好转时间明显短于对照组（P〈0．05）。治疗2周后治疗组显效18例，有效11例，总有效率为96．7％；对照组显效14例，有效13例，总有效率为90．0％，治疗组总有效率明显高于对照组（P〈0．05）。②治疗后两组患者血浆胆红素、转氨酶、血氨均明显降低（P〈0．05），数字连线试验．划线试验时间均明显缩短（P〈0．05），治疗组血氨水平明显低于对照组，差异有统计学意义（P〈0．05）。结论肠道菌群失调在轻型肝性脑病的发病中起到重要的作用，大剂量肠道微生态治疗轻型肝性脑病患者的疗效确切，可以显著改善患者临床症状及肝功能，提高患者生存质量。Objective To observe clinical efficacy of large dose Compound Eosinophil-Lactobacillus in treatment of mild hepatic encephalophathy. Methods Hospitalization patients in the Affiliated Hospital of Ningbo Univerity during January 2012 and January 2014, according to random number table method,were divided into treatment group （n=30） and control group（n=30）. Both groups were given liver support, promote of the blood ammonia supersession and so on treatments,while patients in control group were given conventional tablets （2 tables per time,3 tables per day for 2 weeks） and patients in treatment group were given large dose tablets（5 tables per time, 3 tables per day for 2 weeks）. The clinical main symptoms and signs,blood ammonia change, hepatic function ,time of test of figure ligature and lin- cation were compared in the two groups. Results ①Time of mild improve in treatment group was shorter than in control group.After two weeks-treatment, 18 excellence, 11 effection and 96.7% of the total effective rate in treatment group, 14 excellence, 13 effection and 90.0% of the total effective rate were in the control group. The total effective rate of treatment group was higher than in control group. ②After 2 weeks of treatment, total bilirubin （TBil）, alanine aminotransferase （ALT） and blood ammonia were descended（P〈0.05）,and time of test of figure ligature and lineation were shoter in both two groups（P〈0.05）. The level of blood ammonia in treatment group was lower than that in con- trol group（P〈0.05）, there was significant difference between two groups （P〉0.05）. Conclusion The alteration of in- testinal flora play an important rloe in the nosogenesis of mild hepatic encephalophathy,large dose microecologics in treatment of mild hepatic encephalophathy shows good curative effect, can improve clinical main symptoms, hepatic function, and quality of life

关 键 词：肝性脑病 微生态 复方嗜酸乳杆菌 

分 类 号：R747.9[医药卫生—神经病学与精神病学]