柳氮磺胺吡啶联合美常安或丽珠肠乐治疗溃疡性结肠炎的临床观察  

Clinical observation of Sulfasalazine combined with Medilac-S or Bifidobiogen in the treatment of ulcerative colitis

作　　者：段志英[1] 李凤春[1] 何丽[1] 朱秀芳[1] 霍晓辉[1] 

机构地区：[1]河北医科大学第一医院消化内科,河北石家庄050030

出　　处：《中国医药导报》2015年第25期137-140,共4页China Medical Herald

摘　　要：目的观察柳氮磺胺吡啶联合美常安或丽珠肠乐治疗溃疡性结肠炎（UC）的临床效果。方法选择2012年3月～2014年12月在河北医科大学第一医院接受治疗的UC患者96例进行研究。根据随机数字表法将其分为A、B、C三组。每组各32例。C组单独服用柳氮磺胺吡啶片，A组在C组基础上增用美常安，B组在c组基础上增用丽珠肠乐，比较三组治疗前后大便菌群积分、症状积分降低百分比、Sutherland指数、肠镜分级积分、病理分级积分、肠镜图像及组织学图像，并观察三组并发症发生情况。结果A、B组治疗后大便菌群积分均显著低于治疗前以及C组治疗后，且症状积分降低百分比显著高于C组，差异均有统计学意义（P〈0．01或P〈0．05）。三组治疗后Sutherland指数水平均显著低于治疗前，差异均有高度统计学意义（均P〈0．01）。A、B组治疗后Sutherland指数水平均显著低于C组。且A、B组的变化差值均显著大于C组，差异均有统计学意义（均P〈0．05）。三组治疗后肠镜分级积分及病理分级积分均显著低于治疗前，差异均有高度统计学意义（均P〈0．01）。A、B组治疗后肠镜分级积分及病理分级积分均显著低于c组，且A、B组的变化差值均显著大于C组，差异均有统计学意义（均P〈0．05）。三组并发症发生率比较，差异无统计学意义（P〉0．05）。结论柳氮磺胺吡啶与美常安或丽珠肠乐均可有效治疗UC，且安全性较高，值得临床推广应用。Objective To observe the clinical effect of Sulfasalazine combined with Medilac-S or Bifidobiogen in the treatment of ulcerative colitis （UC）. Methods Ninety six cases of patients with UC who received treatment in the First Hospital of Hebei Medical University from March 2012 to December 2014 were selected to carry on research. They were divided into group A, B, C according to the random number table, with 32 cases in each group. Group C was only given Sulfasalazine Tablets, based on group C, group A was added with Medilac-S, group B was added with Bifidobiogen. The fecal flora scores, decline percentage of symptom scores, Sutherland indexes, colonoscopy classification integral, pathologic grading integral, colonoscopy image and histological image of the three groups before and after treatment were compared, and the incidence of complications among the three groups was compared. Results The fecal flora scores of group A and B after treatment were lower than before treatment and group C after treatment, and the decline percentages of symptom scores were higher than that of group C, the differences were all statistically significant （P 〈 0.01 or P 〈 0.05）. The Sutherland indexes of the three groups after treatment were lower than before treatment, the differences were all highly statistically significant （all P 〈 0.01）. The Sutherland indexes of group A and B after treatment were all lower than that of group C, and the difference values of group A and B were all higher than that of group C, the differences were all statistically significant （all P 〈 0.05）. The colonoscopy classification integral and pathologic grading integral of the three groups after treatment were lower than before treatment, the differences were all highly statistically significant （all P 〈 0.01）. The colonoscopy classification integral and pathologic grading integral of group A and B were lower than that of group C, and the difference values of group A and B were all higher than that of group C, the differences we

关 键 词：柳氮磺胺吡啶 美常安 丽珠肠乐 溃疡性结肠炎 

分 类 号：R574.62[医药卫生—消化系统]