父母生育年龄及母孕期因素与孤独症的关系  

Association of autism with parents' childbearing age and factors during pregnancy

作　　者：齐云柯 卢建平[1,2,3] 寇聪[1,2,3] 柯晓殷 张英[1,2,3] 

机构地区：[1]深圳市康宁医院,深圳518000 [2]深圳市精神卫生中心 [3]深圳市脑神经发育障碍康复技术工程实验室

出　　处：《国际精神病学杂志》2015年第4期8-12,共5页Journal Of International Psychiatry

基　　金：深圳市科技创新委员会资助项目(编号:JCYJ20120829150246301)

摘　　要：目的探讨父母生育年龄及母孕期因素对孤独症发病的影响。方法对符合美国精神障碍诊断与统计手册第4版(DSM-IV)诊断标准的124例孤独症患儿(孤独症组)及健康对照组的父母生育年龄、家族史、母孕期情况进行统计分析。结果母亲生育年龄>29岁孤独症组占比例较对照组高,差异有统计学意义(χ2=10.716,P=0.001),父亲年龄>29岁孤独症组和对照组有显著差异(χ2=15.514,P=0.000),孤独症组母亲孕期使用电脑史所占比例较大,两组差异有统计学意义(χ2=7.893,P=0.005);多因素Logistic回归,结果显示母亲生育年龄、孕期经常使用电脑与孤独症发病相关,可能是孤独症危险因素。结论母亲高生育年龄(>29岁)、孕期经常使用电脑与孤独症的发病相关。Objective To explore the association of autism with parents＇ childbearing age and the perinatal factors. Methods There were 124 patients children with autism and 100 patients control group of children in the case-control study. Questionnaires were used to make up by ourselves to collect childbearing age and factors during pregnancy and other general information. Results Then used Chi-square test to analyze the two sets of children＇s differences in risk factors. The childbearing age of mother in autism group was significantly higher than normal con- trol group （X2= 10. 716, P=0. 001）, also the childbearing age of father （X2= 15. 514, P=0. 000）. Using computer of mother during the pregnant time in autism group were higher than those in the normal control group （ X2= 7. 893, P =0. 005）, and logistic analysis showed that higher childbearing age of mother （〉29 years old）, father introverted, higher maternal induced abortion, maternal depression and passive smoking during the pregnant time were the risk factors to autism in children. Conclusion Mother aged （ ≥ 29 years old）, a history of using computer of mother during the pregnant time are related to autism.

关 键 词：孤独症 父母生育年龄 母孕期因素 

分 类 号：R749.94[医药卫生—神经病学与精神病学]