帕罗西汀对绝经后焦虑抑郁患者雌激素水平和认知功能的影响  

Effects of paroxetine on plasma estrogen level and cognitive function in postmenopausal anxiety-depression patients

作　　者：郑娅丽 赵志才[2] 陈红[1] 史登玉[2] 戴真[2] 李丽[2] 

机构地区：[1]武汉大学中南医院妇产科,武汉430071 [2]十堰市太和医院武当山分院

出　　处：《国际精神病学杂志》2015年第4期69-72,共4页Journal Of International Psychiatry

摘　　要：目的探讨帕罗西汀对绝经后焦虑抑郁患者雌激素水平和认知功能的影响。方法样本为本院2013年9月至2015年2月期间收治的81例绝经后焦虑抑郁患者,所有患者采用帕罗西汀治疗,治疗周期6个月,治疗过程均在医院中完成。治疗前后使用汉密尔顿焦虑量表(HAMA-14)和汉密尔顿抑郁量表(HAMD-17)评估患者的不良情绪,并分别采用酶联免疫吸附测定(ELISA)法和蒙特利尔认知评估量表(Mo CA)测定患者的外周静脉血浆雌激素水平和认知功能。结果 81例患者中有78例完成治疗和随访,治疗后患者的HAMA、HAMD评分明显低于治疗前(P<0.01),E2水平和Mo CA评分显著高于治疗前。结论帕罗西汀可有效治疗绝经后焦虑抑郁患者的情绪症状,提高其血浆E2水平和认知功能。Objective To investigate the effect of paroxetine on estrogen level and cognitive function in post- menopausal anxiety-depression patients. Methods Eighty-one postmenopausal anxiety-depression patients who were hospitalized from 2013 September to 2015 February were treated with paroxetine for 6 months. The patients＇ symptoms were evaluated with HAMA-14 and HAMD-17 scales pre and post the treatment; meanwhile, their plas- ma estrogen levels and cognitive function were measured with enzyme-linked immuno sorbent assay （ELISA） and Montreal Cognitive Assessment （ MoCA）, respectively. Results 78 of these 81 patients were successfully comple- ted with treatment and follow-up. The HAMA and HAMD scores after the treatment were significantly lower than that before the treatment （P〈0. 01 ） ; also, the plasma E2 level and MoCA score were markly higher after than be- fore the treatment （P〈0. 01 ）. Conclusion. Paroxetine can effectively treat the emotional symptoms of postmenopausal anxiety-depression patients, as well as improve their plasma E2 level and cognitive function.

关 键 词：帕罗西汀 绝经 焦虑 抑郁 雌激素 认知功能 

分 类 号：R749.05[医药卫生—神经病学与精神病学]