消脂护肝胶囊对NAFLD大鼠瘦素、胰岛素抵抗的影响  

Influence of Xiaozhihugan Capsule on leptin and insulin resistance in NAFLD rats

作　　者：聂山文[1] 赵文霞[2] 石艳芬[3] 董靖 刘晓彦 马素平[2] 

机构地区：[1]河南省中医院腔镜中心,郑州450002 [2]河南中医学院第一附属医院脾胃肝胆科,郑州450008 [3]河南省焦作市人民医院中医科,河南焦作454002 [4]河南省驻马店市中医院肝胆脾胃科,河南驻马店463000 [5]开封市中医院名中医传承工作室,开封410200

出　　处：《中国当代医药》2015年第23期11-14,共4页China Modern Medicine

摘　　要：目的观察中药消脂护肝胶囊对非酒精性脂肪肝(NAFLD)大鼠的治疗作用,探讨其可能的作用机制。方法采用复合因素复制大鼠NAFLD模型,选取健康雄性SD大鼠72只,按体重随机分为6组,每组12只:空白对照组(简称空白组)、模型对照组(模型组)、东宝肝泰对照组(东宝组)、消脂护肝胶囊高剂量组(消高组)、消脂护肝胶囊中剂量组(消中组)、消脂护肝胶囊低剂量组(消低组)。观察各组大鼠的血糖、血清瘦素(LP)、胰岛素,丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST);血清总胆固醇(TC)、三酰甘油((TG);肝组织病理学。结果与模型组比较,消高组、消中组的LP及胰岛素抵抗(IR)指数均明显下降(P<0.01);与模型组比较,消高组(P<0.01)、消中组(P<0.05)的肝细胞脂变率明显降低。结论消脂护肝胶囊能降低血清LP水平,改善IR状态,对NAFLD有良好的防治作用。Objective To observe the treatment role of Xiaozhihugan Capsule of Chinese medicine for rats with nonalcoholic fatty liver disease（NAFLD）,and to discuss its possible mechanism of action. Methods NAFLD model of rate was copied using composite factor.72 healthy and male rats were divided into 6 groups,and there were 12 rats in each group：blank control group（blank group）,model control group（model group）,dongbaogantai control group（dongbao group）,Xiaozhi Hugan Capsule high dose group（Xiaogao group）, Xiaozhi Hugan Capsule middle dose group（Xiaozhong group）,Xiaozhi Hugan capsule low dose group（Xiaodi group）.Blood sugar,serum leptin（LP）,insulin;serum alanine aminotransferase（ALT）,aspartate aminotransferase（AST）;serum total cholesterol（TC）,triglyceride（TG）;liver tissue pathology was observed of rats in each group respectively. Results Compared with model group,LP and insulin resistance（IR） index in Xiaogao group and Xiaozhong group was obviously decreased respectively（P〈0.01）;Compared with model group,fat change rate of liver cell in Xiaogao group（P〈0.01） and Xiaozhong group（P〈0.05） was obviously decreased respectively. Conclusion Xiaozhihugan Capsule can reduce serum LP level,improve insulin resistance,and has good preventive and therapeutic role for NAFLD.

关 键 词：非酒精性脂肪肝 瘦素 胰岛素抵抗 消脂护肝胶囊 

分 类 号：R575.5[医药卫生—消化系统]