阿苯达唑纳米混悬液的冻干工艺优化  

Optimization of Freeze-drying Technology of Albendazole Nanosuspension

作　　者：任洁如 马运芳[2] 王建华[2] 陈迹[2] 

机构地区：[1]新疆医科大学基础医学院,乌鲁木齐830054 [2]新疆医科大学第一附属医院,乌鲁木齐830054

出　　处：《中国药房》2015年第25期3575-3577,共3页China Pharmacy

基　　金：新疆维吾尔自治区包虫病基础医学重点实验室阿苯达唑纳米微粉的生物利用度研究项目(XJDX0202-2013-5)对本文的资金支持

摘　　要：目的:优化阿苯达唑纳米混悬液的冻干工艺,制备阿苯达唑纳米微粉。方法:采用冷冻干燥法,以粒径、Zeta电位为指标,对预冻温度和冻干保护剂的种类、配比及质量分散进行单因素试验考察及验证,将液相沉淀法制备的阿苯达唑纳米混悬液,制备成阿苯达唑纳米微粉。结果:预冻温度为-20℃、冻干保护剂为4%葡萄糖-甘露醇(3∶7)时,所制纳米微粉的平均粒径为(208.03±2.13)nm,平均Zeta电位为(-15.53±0.18)m V。结论:该冻干工艺可制得粒径、电位较优的阿苯达唑纳米微粉。OBJECTIVE：To optimize freeze-drying technology of albendazole nanosuspension so as to prepare albendazole nanometer powder. METHODS：By adopting freeze-drying method,with particle size and Zeta potential as the indexes,single factor test and verification were made on pre-freezing temperature and the type,ratio and mass fraction of cryoprotectants,and then the albendazole nanosuspension prepared by liquid phase precipitation method was made into albendazole nanometer powder. RESULTS：When the pre-freezing temperature was-20 ℃ and the cryoprotectant was 4% glucose-mannitol（3 ∶ 7）,the average particle size of the prepared nanometer powder was（208.03±2.13）nm,and average Zeta potential was（-15.53±0.18）m V. CONCLUSIONS：Albendazole nanometer powder with better particle size and potential can be prepared by freeze-drying technology.

关 键 词：阿苯达唑 纳米混悬液 冻干保护剂 冷冻干燥 

分 类 号：R943[医药卫生—药剂学]