microRNA在JAK-STAT信号通路中的研究进展  

Research progress of microRNA in JAK/STAT signal pathway

作　　者：袁天蔚 马中良[1] 金由辛[1,2] 

机构地区：[1]上海大学生命科学学院,上海200444 [2]中国科学院上海生命科学研究院生化与细胞所,上海200031

出　　处：《生命的化学》2015年第4期495-503,共9页Chemistry of Life

基　　金：2013年上海市"教师专业发展工程";国家自然科学基金项目(31170750)

摘　　要：信号转导和转录激活因子(signal transducers and activators of transcription,STAT)是许多细胞因子、生长因子和激素作用途径中的关键蛋白质,它参与细胞的增殖、分化、迁移和凋亡调控。miRNA在各种肿瘤发生和免疫反应中具有广泛的调控功能。本文总结了近年来miRNA在JAK-STAT信号通路中的研究进展,以及二者在肿瘤治疗和免疫方面的应用,为相关疾病的研究和治疗提供思路。Signal transducers and activators of transcription （STATs） proteins are the key signaling proteins of specific cytokines, growth factors and hormones. STATs could regulate cell proliferation, differentiation, migration and cell-apoptosis through JAK/STAT signal pathway, miRNAs are emerging as important gene expression regulators involved in varieties of biological pathways, such as tumorigenesis and immunity. In this review, we have discussed the research progress between miRNAs and STATs. We have summarized their functions and application in cancer therapy and immunity, which could provide new insights into the treat- ments of the related diseases.

关 键 词：MIRNA STAT 肿瘤 免疫 

分 类 号：R73-3[医药卫生—肿瘤]