DNA损伤修复蛋白在炎症免疫反应中的作用  

The role of DNA damage repair proteins in inflammatory immune response

作　　者：贾金婧[1] 曾宪思[1] 

机构地区：[1]信阳师范学院生命科学学院,信阳464000

出　　处：《生命的化学》2015年第4期549-552,共4页Chemistry of Life

基　　金：信阳师范学院博士科研启动基金项目(0201427)

摘　　要：细胞代谢或细胞应激均可以引起DNA损伤。DNA损伤可以引起一系列级联反应即DNA损伤反应。炎症免疫反应是活体组织对损伤因子所起的防御反应。DNA损伤反应与炎症的发生发展密切相关,而DNA损伤修复蛋白在免疫系统中具有重要作用。本文将就DNA损伤修复蛋白在炎症免疫反应中的作用及其机制进行综述。Oxidative DNA damage can be induced by cellular metabolism and cellular stress. DNA damage results in series of cascades, namely DNA damage response. Inflammatory immune response is a defensive reaction to damage factors in living tissues. DNA damage is implicated in inflammation. And DNA damage repair proteins play important roles in immune system. This paper reviews the role of DNA damage repair proteins in inflammatory immune response and its mechanisms.

关 键 词：DNA损伤 DNA损伤修复蛋白 炎症 免疫反应 

分 类 号：R363[医药卫生—病理学]