血管性痴呆病因及发病机制的研究进展  

Research update on the etiology and pathogenesis of vascular dementia

作　　者：钟汝佳 陶定波[2] 乐卫东[1] 

机构地区：[1]大连医科大学附属第一医院辽宁省神经疾病转化医学中心,辽宁大连116011 [2]大连医科大学附属第一医院神经科,辽宁大连116011

出　　处：《转化医学杂志》2015年第4期193-198,共6页Translational Medicine Journal

基　　金：国家自然科学基金重点项目(81430021);国家自然科学基金面上项目(80370470)

摘　　要：血管性痴呆是指脑组织损害基础上产生的以高级神经认知功能障碍为主的一组临床综合征,是导致老年痴呆的第2位原因,但其确切的发病机制目前还不明确。进一步明确与血管性痴呆病因相关的危险因素并深入探讨其分子机制和遗传机制,以转化医学为突破口,推进对脑血管病的研究和发展,对该病的临床预防和治疗具有重要意义。Vascular dementia (VD) is characterized by histopathological damage and pro-gressive intellectual decline produced by cerebral ischemic hypoxia or hemorrhagic lesion.VD is the second most common form of dementia after Alzheimer’s disease and its incidence is increasing with aging.It is generally accepted that brain ischemia-hypoxia is the main cause of VD, but the exact pathogenic mechanisms of VD is still not clearly demonstrated .Therefore, further confirming the eti-ology for VD and exploring the molecular and genetic mechanisms underlying have great significance for the diagnosis, prevention and treatment of VD in translational medicine.

关 键 词：血管性痴呆 转化医学 病因 危险因素 发病机制 

分 类 号：R749.16[医药卫生—神经病学与精神病学]