经导管动脉化疗栓塞术对肝癌转移潜能的影响  

Effect of transcatheter arterial chemoembolization on metastasis potential of hepatocellular carcinoma

作　　者：康振[1] 肖恩华[1] 

机构地区：[1]中南大学湘雅二医院放射科,湖南省长沙市410011

出　　处：《世界华人消化杂志》2015年第20期3182-3187,共6页World Chinese Journal of Digestology

基　　金：湖南省社发领域科技支撑计划项目;No.2015SF2020-4~~

摘　　要：经导管动脉化疗栓塞术(transcatheter arterial chemoembolization,TACE)是治疗中晚期肝癌的重要方法,但其是否促进肝癌的转移潜能,目前研究观点尚不统一.TACE可通过抑制肝癌细胞增殖,促进肿瘤细胞凋亡,促使抑癌因子表达增加,降低部分肿瘤血管生成因子的表达,使肝癌患者获益并降低肝癌转移潜能;但也可能使部分肿瘤血管生成因子表达增加,改变肝癌供应血流动力学,对患者免疫及病毒载量一些可能的负面影响而成为肝癌转移的潜在危险因素.本文从TACE对肿瘤细胞、血管改变及生成、免疫、病毒的影响各方面作一综述,阐述TACE对肝癌转移潜能的可能影响.Transcatheter arterial chemoembolization （TACE） is an important treatment method for advanced hepatocellular carcinoma （HCC）, but whether it promotes the metastasis potential of HCC is still controversial. TACE can inhibit tumor cell proliferation, promote tumor cell apoptosis, increase the expression of tumor-suppressorfactors, and decrease the expression of some tumor angiogenesis factors, thus benefiting HCC patients and decreasing the metastasis potential of HCC. However, TACE could increase the expression of some angiogenesis factors, change the hemodynamics of HCC, and bring some adverse impacts on patients＇ immune system and HBV load, which could potentially lead to HCC metastasis. This review summarizes the impacts of TACE on tumor cells, tumor hemodynamics, angiogenesis, immune function and HBV load, with an aim to elucidate the effect of TACE on HCC metastasis potential.

关 键 词：经导管动脉化疗栓塞术 肝癌 转移 细胞凋亡 抑癌因子 肿瘤血管生成因子 免疫 乙型肝炎病毒 

分 类 号：R735.7[医药卫生—肿瘤]