益生菌增效治疗幽门螺杆菌感染的Meta分析再评价  

Probiotics as adjunctive therapy for Helicobacter pylori infection: An overview of meta-analyses

作　　者：周本刚[1] 肖政[2] 汪成琼 刘梅[1] 李仕宇 陈安海[1] 

机构地区：[1]遵义医学院附属医院消化内科,贵州省遵义市563003 [2]遵义医学院循证医学中心循证医学教育部网上合作研究中心遵义医学院分中心,贵州省遵义市563003

出　　处：《世界华人消化杂志》2015年第20期3326-3336,共11页World Chinese Journal of Digestology

基　　金：贵州省科技厅社会发展公关基金资助项目;No.黔科合SY字[2011]3056号~~

摘　　要：目的:对益生菌增效治疗幽门螺杆菌(Helicobacter pylori,H.pylori)感染的系统评价/Meta分析进行再评价研究.方法:计算机检索CBM、CNKI、Wanfang Data、VIP Data、the Cochrane library、PubMed、Embase数据库,收集关于益生菌增效治疗H.pylori感染的系统评价/Meta分析文章,检索时间均从建库至2014-10.由两位研究者按照纳入排除标准独立筛选文献、提取资料后,采用OQAQ(Overview Quality Assessment of Questionnaire)量表评价纳入研究质量,并采用GRADE(Grade o f R e c o m m e n d a t i o n,A s s e s s m e n t,Development,and Evaluation)系统进行证据质量分级.结果:共纳入11个相关Meta分析,11个研究均评价了益生菌增效治疗H.pylori的根除率及总不良反应发生率,其中3个研究详细评价了抗H.pylori具体不良反应发生率,OQAQ平均得分3.82分.GRADE系统的证据质量评价结果显示证据质量等级普遍较低.结论:当前益生菌增效治疗H.pylori感染具有一定的优势,但Meta分析的总体质量较差,证据水平较低,临床医生应根据实际情况进行循证决策.AIM： To evaluate the relevant systematic reviews/meta-analyses that focused on probiotics as adjunctive therapy for Helicobacter pylori （H. pylori） infection. METHODS： The systematic reviews/meta- analyses on probiotics as adjunctive therapy for H. pylori infection were searched in CBM, CNKI, Wanfang database, VIP Database, the Cochrane library, PubMed and Embase from inception to October 2014. Two reviewers screened the literature according to the inclusion criteria and extracted the data. The Overview Quality Assessment Questionnaire （OQAQ） was used to evaluate the quality of the included studies, and the GRADE system was used to evaluate the quality of evidence. RESULTS： A total of 11 relevant meta-analyses were included, all of which evaluated the rate of H. pylori eradication and incidence of overall side effects （three evaluated the anti-H, pylori therapy-related side effects in detail）. The mean OQAQ score was 3.82. Based on the GRADE system, the evidence quality was generally low. CONCLUSION： Probiotics as adjunctive therapy for H. pylori infection have certain advantages, however, the overall quality of meta-analyses is poor, and the evidence level is low. Physicians should make an evidence-based decision according to the real condition.

关 键 词：益生菌 幽门螺杆菌 系统评价/META分析 系统评价再评价 OQAQ GRADE系统 

分 类 号：R57[医药卫生—消化系统]