子宫内膜癌组织中趋化因子CXCL12及其受体 CXCR4表达水平研究  

Expression of Chemokine CXCL12 and Its Receptor CXCR4 in Endometrial Carcinoma Tissues

作　　者：郑福利[1] 党淼[1] 张淼芳[1] 王建[2] 

机构地区：[1]陕西中医药大学第二附属医院妇产科,陕西咸阳712000 [2]第四军医大学西京医院妇产科,西安710032

出　　处：《现代检验医学杂志》2015年第4期21-23,27,共4页Journal of Modern Laboratory Medicine

基　　金：国家自然科学基金资助项目（No.81172458）.

摘　　要：目的：观察子宫内膜癌组织中趋化因子 CXCL12及其受体 CXCR4表达水平，探讨其与子宫内膜癌患者临床病理特征相关性。方法收集2012年1月～2014年12月间入院接受手术的子宫内膜癌患者52例病理标本，年龄55.6±19.2岁，以正常子宫内膜26例为对照组，年龄52.3±16.5岁。采用免疫组化技术检测趋化因子 CXCL12及其受体 CX-CR4在子宫内膜癌组织中的表达情况，并分析它们与 FIGO 分期、细胞分化程度、淋巴结转移和病理类型等临床病理特征的关系。结果CXCL12和 CXCR4在子宫内膜癌组织中阳性表达率分别为76.92％和69.23％，而在正常子宫内膜组织中则分别为34.62％和30.77％，差异具有统计学意义（χ2＝11.826，P ＜0.01）。CXCR4的表达与子宫内膜癌细胞分化程度存在差异，有统计学意义（均 P ＜0.05），且与分化高低呈正相关（r＝0.386，P ＜0.05）。在子宫内膜癌组织中，除 CXCR4表达与细胞分化程度呈正相关外，CXCL12和 CXCR4表达与临床分期、淋巴结转移和病理类型无相关性（P ＞0.05）。结论CXCL12和 CXCR4在子宫内膜癌组织中表达明显升高，这可能在子宫内膜癌发生发展过程中发挥重要生物学作用。Objective To observe the translations of chemokine CXCL12 and its receptor CXCR4 in endometrial carcinoma tissues,and to evaluate their significance in clinical pathologic features of endometrial carcinoma.Methods From Jan.2012 to Dec.2014,52 tissue specimens of patients with endometrial carcinoma were admitted to the hospital,aged 55.6 ± 19.2 years,and 26 cases of normal endometrium as control,aged 52.3±16.5 years old.Expressions of CXCL12 and CXCR4 in the tissue specimens were detected by immunohistochemistry,and to analyze the relationship between the expressions and clini-cal pathological features,and FIGO stage,cell differentiation,lymph node metastasis and pathological type in endometrial carcinoma.Results In endometrial carcinoma,the positivity rates of CXCR4 and CXCL12 were 76.92% and 69.23% re-spectively.The positive expression rates of which were 34.62% and 30.77% in normal endometrium tissues,statistically significant （χ2 =11.826,P 〈0.01）.The expression of CXCR4 was positively correlated with the differentiation of endome-trial carcinoma cells （P 〈0.05）.In endometrial carcinoma,with the exception of CXCR4 expression and cell differentiation was positively related （r=0.386,P 〈0.05）,CXCL12 and CXCR4 expression and clinical stage,pathological type and lymph node metastasis no correlation was found （P 〉0.05）.Conclusion The results showed that the expression of CXCL12 and CXCR4 in endometrial carcinoma tissues was significantly increased,which may play an important role in the development of endometrial cancer.

关 键 词：子宫内膜肿瘤 趋化因子CXCL12 CXCR4 

分 类 号：R737.33[医药卫生—肿瘤] R730.43[医药卫生—临床医学]