单纯放疗、热放疗与放化疗治疗食管癌的效果比较  

Comparative analysis of radiotherapy alone, thermoradiotherapy and radiotherapy and chemotherapy of esophageal cancer effect

作　　者：刘岩峰[1] 郭辉[1] 苏山峰 

机构地区：[1]山东省单县中心医院肿瘤科二病区,274300

出　　处：《中国基层医药》2015年第15期2250-2253,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：比较单纯放疗、热放疗与放化疗治疗食管癌的临床疗效。方法选择食管癌患者120例为研究对象，按数字表法随机分为单纯放疗组、热放疗组、放化疗组，每组40例，分别给予单纯放疗、热放疗和放化疗治疗。比较三组的治疗效果及不良反应。结果三组患者治疗过程中的主要毒性反应为消化系统不良反应、血液学毒性以及放射性食管炎等，三组毒性反应发生率差异无统计学意义（P ＞0．05）；单纯放疗组、热放疗组、放化疗组总缓解率分别为52．5％、75．0％、85．0％，放化疗组总缓解率均高于单纯放疗组、热放疗组（χ2＝5．218、3．857，均 P ＜0．05）。结论不同方法治疗食管癌均能获得一定的治疗效果，但存在一定的不良反应；放化疗治疗食管癌较之单纯放疗和热放疗可以获得更好的效果。Objective To comparative analysis the effect of radiotherapy, thermoradiotherapy and chemora- diotherapy on esophageal cancer. Methods 120 patients with esophageal carcinoma were selected and randomly divided into the radiotherapy group, thermoradiotherapy groupand chemoradiotherapy group by digital table method, with 40 cases in each group, which were treated with radiotherapy alone, thermoradiotherapy alone and radiotherapycombine with chemotherapy respectively. The effects of treatment of the three groups were compared. Results The main toxic reaction in the three groups during the treatment for adverse reaction were digestive system reaction, hema- tologic toxicities and radioactive esophagitis. The incidence of toxic reaction of the three groups were not statistically significant （ P 〉 0.05 ）. Total response rate of simple radiotherapy group, the thermal radiation group, chemoradiothera- py group were 52.5% ,75.0% and 85.0%. ,The total remission rate of chemotherapy group was higher than those of the radiotherapy group and the thermal radiation group （ χ2 = 5.218,3. 857, all P 〈 0.05 ）. Conclusion The different treatment methods of esophageal cancer can obtain certain curative effect, but there are some adverse reactions. Among different treatment methods, radiotherapy and chemotherapy in the treatment of esophageal carcinoma can get better effect than the radiotherapy and chemoradiotherapy.

关 键 词：放射疗法 化学疗法 抗肿瘤治疗方案 联合 食管肿瘤 

分 类 号：R735.1[医药卫生—肿瘤]