COX-2与淋巴结转移对宫颈癌预后影响的研究  

Effects of COX-2 and lymph-node metastasis on prognosis of cervical cancer

作　　者：辛华栋[1] 张莉华[2] 武艳霞[2] 焦茹[3] 吴士茜[4] 袁艳龙[5] 

机构地区：[1]邯郸市第一医院神经内科,河北邯郸056001 [2]邯郸市中心医院妇二科,河北邯郸056001 [3]邯郸市中心医院口腔外科,河北邯郸056001 [4]邯郸市中心医院体检中心,河北邯郸056001 [5]邯郸市中心医院病理科,河北邯郸056001

出　　处：《癌症进展》2015年第4期435-438,共4页Oncology Progress

摘　　要：目的研究环氧合酶-2(cyclooxygenase-2,COX-2)及淋巴结转移对宫颈癌预后的影响。方法采用免疫组化SP法,检测95例宫颈癌患者中COX-2的表达情况,并采用生存分析法评估COX-2表达与淋巴结转移对宫颈癌预后的影响。结果 COX-2在95例宫颈癌中的阳性表达率为65.26%(62/95),COX-2的阳性表达与淋巴结转移、宫旁或脉管浸润呈正相关(r=0.220,P=0.032;r=0.215,P=0.037)。生存分析显示,COX-2阳性表达(P=0.005)、淋巴结转移(P=0.000)与宫颈癌患者的预后密切相关。结论 COX-2及淋巴结转移是宫颈癌患者预后的独立影响因素,对判断预后及指导治疗具有重要的临床价值。Objective To study the effects of COX-2 and lymph-node metastasis on the prognosis of cervical can-cer. Method The expression of COX-2 was identified by immunohistochemically S-P method in the paraffin sec-tions, and survival analysis was applied to evaluated the effect of COX-2 expression and lymph-node metastasis on the prognosis of cervical cancer, while Kaplan-Meier plots provided. Result The positive expression rate of COX-2 was 65.26% （62/95） in 95 patients with cervical cancer, which was positively associated with lymph-node metastasis and latero-uterus or vessel infiltration （r=0.220, P=0.032; r=0.215, P=0.037, respectively）. Survival analysis indicated that positive expression of COX-2 and lymph-node metastasis were both closely related with the prognosis of cervical cancer （P=0.005; P=0.000, respectively）. Conclusion COX-2 and lymph-node metastasis are independent prognosis factors in cervical cancer, which may serve as predictors with clinical importance.

关 键 词：宫颈癌 环氧合酶-2 淋巴结转移 预后 

分 类 号：R737.3[医药卫生—肿瘤]