利用肝静脉血流动力学判定肝纤维化严重程度  

The applying values of hepatic hemodynamics in the diagnosis of liver fibrosis

作　　者：张宏女 王红英 张才琴 

机构地区：[1]扬州市第三人民医院B超室,江苏扬州225000

出　　处：《国际病毒学杂志》2015年第4期256-260,共5页International Journal of Virology

摘　　要：目的 探讨肝静脉血流动力学分析在肝纤维化诊断中的应用价值.方法 2012年9月-2014年8月选择在扬州市第三人民医院接受检查的慢性乙型肝炎患者80例,其中轻度肝纤维化40例（轻度肝纤维化组）,中度肝纤维化30例（中度肝纤维化组）,重度肝纤维化10例（重度肝纤维化组）,都进行了肝静脉血流动力学分析、血清肝纤维化指标检测与肝脏硬度检测.结果 随着肝纤维化程度的加重,患者的肝-门静脉过渡时间呈现明显降低的趋势（P＜0.05）,血清纤维化四项指标（HA、LN、PⅢP、Ⅳ-C）测定值呈明显增加趋势,肝脏硬度也呈现明显增加的趋势,组间对比差异都有统计学意义（P＜0.05）.Spearman相关分析显示肝-门静脉过渡时间与肝脏纤维化程度呈负相关（P＜0.05）,而血清纤维化四项指标含量、肝脏硬度与肝脏纤维化程度呈正相关（P＜0.05）.结论 肝静脉血流动力学分析结合肝脏功能其他指标,可用于肝脏纤维化诊断中的应用能有效判定疾病状况,值得推广应用.Objective To investigate the feasibility and values of hepatic hemodynamics in the diagnosis of liver fibrosis.Methods 80 chronic hepatitisB patients were selected from September 2012 to August 2014 in our hospital for examination.40 patients were mild liver fibrosis,30 patients were moderate hepatic fibrosis and 10 patients were severe liver fibrosis.All of the patients were given hepatic hemodynamics study,serum fibrosis markers detecting and liver hardness testing.Results With the severity of liver fibrosis,the HVAT and VVT values showed significant decreased （P 〈 0.05）.The serum HA,LN,C-Ⅳ and P Ⅲ P content showed increasing trend,liver hardness showed significant increasing trend.There was significant differences among the groups （P 〈 0.05）.Spearman correlation analysis showed HVAT and VVT had negative correlation （P 〈 0.05）,whereas serum HA,LN,C-Ⅳ and P Ⅲ P contents,liver stiffness to the liver fibrosis showed significant positive correlation （P 〈 0.05）.Conclusions Hepatic hemodynamics can be used to dynamically non-invasive diagnostic liver disease.Combined with other indicators of liver function in liver fibrosis diagnostic applications,it can be used to understand the state of disease that could be widely applied.

关 键 词：肝静脉血流动力学分析 肝脏纤维化 肝脏硬度 血清学分析 

分 类 号：R575.2[医药卫生—消化系统]