IMP3蛋白在子宫颈癌中的表达及其与MVD的关系  

Relationship between expression of IMP3 protein and MVD in cervical carcinoma

作　　者：李明[1] 张亚军[1] 

机构地区：[1]江苏省连云港市妇幼保健院妇科,江苏连云港222002

出　　处：《海南医学院学报》2015年第10期1322-1324,1328,共4页Journal of Hainan Medical University

基　　金：连云港市卫生局课题(1325)~~

摘　　要：目的:研究IMP3与MVD在正常宫颈组织,CIN、宫颈鳞癌中的表达,探讨其与宫颈癌发生发展的关系。方法:采用免疫组化方法S-P分别检测IMP3与MVD在50例宫颈浸润癌组织、35例CIN组织、15例宫颈炎组织中的表达。结果:IMP3及MVD在宫颈癌、CIN、正常宫颈组织表达两两比较有显著差异(P﹤0.05)。宫颈癌组织中IMP3及MVD值高表达,且宫颈癌临床分期,淋巴转移、分化程度与其具有相关性(P﹤0.05),IMP3及MVD值在宫颈癌组织表达具有相关性(r=0.323,P=0.022)。结论:IMP3及MVD与宫颈癌的发生及侵袭转移有关,可以作为宫颈癌恶性程度及预后的良好指标。Objective To study the expressions of IMP3 and MVD in normal cervical tissue, CIN, and squamous cell carcinoma of cervix and to investigate their relationship with the occurrence and development of cervical carcinoma. Methods： Immunohistochemistry S-P method was used to detect the expressions of IMP3 and MVD in 50 cervical invasive carcinoma tis sues, 35 CIN tissues and 15 cervicitis tissues respectively. Results： There were significant differences in the expressions of IMP3 and MVD among cervical carcinoma, CIN and normal cervical tissues （P^0.05）. IMP3 and MVD value were highly ex- pressed in cervical carcinoma tissues, and were correlated with clinical staging, lymphatic metastasis and differentiation degree of cervical carcinoma （P〈0.05） ; IMP3 and MVD value were correlated with their expressions in cervical carcinoma tissues （r = 0. 323,P=0. 022）. Conclusions .- IMP3 and MVD are associated with the occurrence as well as the invasion and metastasis of cervical carcinoma, and can be used as proper indicators of the malignancy degree and prolznosis of cervical carcinoma.

关 键 词：宫颈组织 IMP3 MVD 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]