氩氦刀冷冻消融术对老年Ⅲ、Ⅳ期非小细胞肺癌患者肿瘤转移及并发症的影响  

Impact of argon helium cryoablation(ahc)on tumor metastasis and complications of elderly patients withⅢ,Ⅳ stage of non-small-cell carcinoma(nsclc)

作　　者：刘茂鸿 张红[1] 张琼[1] 

机构地区：[1]郫县人民医院呼吸内科,四川成都611730

出　　处：《海南医学院学报》2015年第10期1365-1367,共3页Journal of Hainan Medical University

基　　金：四川省卫生厅资助项目(201101324)~~

摘　　要：目的:研究分析氩氦刀冷冻消融术(argon helium cryoablation,AHC)对老年Ⅲ、Ⅳ期非小细胞肺癌(NSCLC)患者肿瘤转移及并发症的影响。方法:选取本院收治的老年Ⅲ、Ⅳ期NSCLC患者60例作为研究对象,随机分成观察组和对照组,每组30例。对照组单纯应用化疗方式治疗,观察组应用AHC联合化疗方式治疗。对比两组治疗后3个月临床疗效情况、两组治疗后随访1年肿瘤转移、复发情况及生存情况以及治疗后并发症发生情况。结果:观察组治疗后3个月治疗总有效率及临床获益率均明显高于对照组,观察组治疗后随访1年,其复发率及肿瘤转移率均明显低于对照组,1年生存率高于对照组,差异均有统计学意义(P<0.05);两组术后咳血、痰中带血、气胸、发热并发症发生率比较,差异无统计学意义(P>0.05)。结论:AHC联合化疗方式治疗老年Ⅲ、Ⅳ期NSCLC与单纯化疗方式相比较,临床效果更佳,且AHC更佳安全可靠,能够降低肿瘤转移,值得临床推荐。Objective.. To study impact of argon helium cryoablation （AHC） on tumor metastasis and complications of elderly patients with Ⅲ、Ⅳ stage of non-small-cell carcinoma （NSCLC）. Method： Selected 60 cases of elderly patients with Ⅲ、Ⅳ stage of NSCLC who accepted treatment in our hospital and divided them into observation group and control group by a- dopting numbering approach with 30 cases in each group. Applied chemotherapy alone for patients in control group, and ap- plied AHC combining with chemotherapy for patients in observation group. Compared clinical efficacy three months after the treatment, tumor metastasis one year after follow-up treatment, relapse, survival status and complications occurrence status of patients in the two groups were also compared. Results： Three months after the treatment, the total effective rate and clinical benefit rate of observation group are significantly higher than that of control group. One year follow-up data showed the relapse rate and tumor metastasis rate of observation group were significantly lower than that of control group, and one year survival rate was significantly higher than that of control group. The occurrence rate of complications, such as postoperative hemopty- sis, blood-stained sputum, pneumothorax and pyrexia of the two groups was not significant different between the two groups （P〈0.05）. Conclusion： Compared with single chemotherapy, AHC combining with chemotherapy has better clinical effects onelderly patients with Ⅲ、Ⅳ stage of NSCLC. Besides, AHC is safer and more reliable, and can reduce tumor metastasis. Thus it is worthy of clinical recommendations.

关 键 词：氩氦刀冷冻消融术 非小细胞癌 肿瘤转移 并发症 

分 类 号：R734.2[医药卫生—肿瘤]