声触诊组织量化技术与病理胶原蛋白评价原发性肝癌硬度的相关研究  

The stiffness of primary liver cancer：the relationship between virtual touch tissue quantification and collagen percentage assay

作　　者：薛薇[1] 赵玉珍[1] 何其佳[1] 阳练 笪冀平[2] 蒋惠君[2] 

机构地区：[1]中日友好医院超声科,北京100029 [2]中日友好医院病理科,北京100029

出　　处：《中华超声影像学杂志》2015年第8期680-683,共4页Chinese Journal of Ultrasonography

摘　　要：目的探讨声触诊组织量化（virtual touch tissue quantification，VTQ）技术与病理胶原蛋白评价原发性肝癌硬度的相关性。方法40例原发性肝癌患者术前行VTQ检测，获取肿瘤组织及癌周组织的剪切波速度（shear wave velocity，SWV）值，所得测值与术后病理组织免疫组化染色计测的胶原蛋白含量对照，进行相关性分析。结果原发性肝癌肿瘤组织的SWV值明显大于癌周组织[（2．82±0．68）m／s对（1．66±0．47）m／s，P〈O．os]；肿瘤组织的胶原蛋白含量明显多于癌周组织[天狼星红染色组：（74．68±11．29）％对（41．59±17．85）％，P〈0．05；Masson染色组：（75．47±11．11）％对（40．41±17．12）％，P〈0．05]；原发性肝癌肿瘤内部swV值与病理胶原蛋白含量呈正相关（天狼星红染色组：r=0．70，P〈0．05；Masson染色组：r=0．73，P〈0．05）。结论原发性肝癌SwV值与病理胶原含量有良好的相关性，为SWV值定量评价肝癌硬度提供了病理依据。Objective To study the relativity between virtual touch tissue quantification（VTQ） and collagen percentage assay in the stiffness of primary liver cancer（PLC）. Methods Forty patients with PLC were examined with virtual touch tissue quantification （VTQ） to obtain the shear wave velocity（SWV） before operation. These parameters were compared with collagen percentage assay counted with immunohistochemistry,and the correlation was statistically studied. Results Significant differences in mean SWV appeared between tumor tissues and background liver tissues of these PLC [2.82 ±0.68） m/s vs （1.66 ±0.47）m/s, P〈0.05]. The collagen percentage assay of tumor tissues was significantly higher than that of background liver tissues [Sirius red group.. （74.68 ±11.29）% vs （41.59 ± 17.85） %, P〈 0.05 ; Massongroup： （75.47±11.11）% vs （40.41 ±17.12）%, P 〈0.05]. The SWV before operation was correlated positively to collagen percentage assay （Sirius red group： r = 0.70, P〈0.05 ;Masson group： r = （1.73, P 〈0.05） of histological section after operation. Conclusions SWV value calculated by VTQ has reasonable correlation with collagen percentage assay of tumors, it is a valuable index for quantitative evaluation of the stiffness of liver cancer.

关 键 词：超声检查 肝肿瘤 声触诊组织量化 胶原蛋白含量 

分 类 号：R735.7[医药卫生—肿瘤] R730.41[医药卫生—临床医学]