肝功能异常与小肠黏膜病变的研究进展  

Progress on liver dysfunction and small intestinal diseases

作　　者：陈美慧[1] 何兴祥[2] 蔡洁毅[2] 

机构地区：[1]广东药学院临床学院,广东广州510310 [2]广东药学院第一附属医院消化内科,广东广州510080

出　　处：《广东药学院学报》2015年第4期558-560,F0003,共4页Academic Journal of Guangdong College of Pharmacy

摘　　要：肠道的微生物菌群不仅参与营养物质的消化,还可作为一道免疫屏障,对抗病原微生物。肠道微生物菌群移位(microbial translocation,MT)不仅可见于肝硬化患者,也可出现在包括酒精性肝病和非酒精性脂肪性肝病在内的慢性肝脏疾病的早期阶段,MT与肝硬化的并发症相关,是肝硬化发病率和病死率显著增高的原因。我们通过动物实验和临床研究,发现肝功能异常与小肠黏膜病变关系密切,本文对这一问题进行综述。Intestinal microflora has been found involving in digestion of nutrients,and acting as an immune barrier against pathogens. New studies show that the intestinal microbial translocation（ MT） happened not only in patients with liver cirrhosis,also in the early stages of chronic liver diseases such as alcoholic and non-alcoholic fatty livers. More researches have proved that microbial translocation was associated with cirrhosis-related complications,and became the critical factor for the higher morbidity and mortality of liver cirrhosis. Meantime,we also found the relationship between the abnormal liver function and intestinal mucosal lesions in animal experiments and clinical studies. This paper will give a review on recent these findings.

关 键 词：非酒精性脂肪性肝病 肝硬化 酒精性肝病 小肠黏膜病变 

分 类 号：R574.5[医药卫生—消化系统]