Microflow-induced shear stress on biomaterial wall by ultrasound-induced encapsulated microbubble oscillation  

作　　者：胡继文 钱盛友 孙佳娜 吕云宾 胡苹 

机构地区：[1]School of Mathematics and Physics,University of South China [2]School of Physics and Information Science,Hunan Normal University

出　　处：《Chinese Physics B》2015年第9期307-312,共6页中国物理B（英文版）

基　　金：Projects supported by the National Natural Science Foundation of China(Grant Nos.11174077 and 11474090);the Natural Science Foundation of Hunan Province,China(Grant No.13JJ3076);the Science Research Program of Education Department of Hunan Province,China(Grant No.14A127);the Doctoral Fund of University of South China(Grant No.2011XQD46)

摘　　要：A model of an ultrasound-driven encapsulated microbubble（EMB） oscillation near biomaterial wall is presented and used for describing the microflow-induced shear stress on the wall by means of a numerical method. The characteristic of the model lies in the explicit treatment of different types of wall for the EMB responses. The simulation results show that the radius-time change trends obtained by our model are consistent with the existing models and experimental results. In addition, the effect of the elastic wall on the acoustic EMB response is stronger than that of the rigid wall, and the shear stress on the elastic wall is larger than that of the rigid wall. The closer the EMB to the wall, the greater the shear stress on the wall. The substantial shear stress on the wall surface occurs inside a circular zone with a radius about two-thirds of the bubble radius. This paper may be of interest in the study of potential damage mechanisms to the microvessel for drug and gene delivery due to sonoporation.A model of an ultrasound-driven encapsulated microbubble（EMB） oscillation near biomaterial wall is presented and used for describing the microflow-induced shear stress on the wall by means of a numerical method. The characteristic of the model lies in the explicit treatment of different types of wall for the EMB responses. The simulation results show that the radius-time change trends obtained by our model are consistent with the existing models and experimental results. In addition, the effect of the elastic wall on the acoustic EMB response is stronger than that of the rigid wall, and the shear stress on the elastic wall is larger than that of the rigid wall. The closer the EMB to the wall, the greater the shear stress on the wall. The substantial shear stress on the wall surface occurs inside a circular zone with a radius about two-thirds of the bubble radius. This paper may be of interest in the study of potential damage mechanisms to the microvessel for drug and gene delivery due to sonoporation.

关 键 词：encapsulated microbubble shear stress SONOPORATION 

分 类 号：O35[理学—流体力学]