supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF);funded by the Ministry of Education,Science,and Technology(NRF-2016R1A6A1A03012845,NRF-2022M3E5F1017553),Republic of Korea;the Ministry of Food and Drug Safety grant(22213MFDS421),Republic of Korea.
Lipid-coated microbubbles are widely used as an ultrasound contrast agent,as well as drug delivery carriers.However,the two main limitations in ultrasound diagnosis and drug delivery using microbubbles are the short h...
supported in part by the Natural Sciences and Engineering Council of Canada (CREATE-528202-2019);Canadian Institutes of Health Research (PJT-153240);the Ministry of Science and Technology Key Research and Development Plan of China (No.2018YFC0115901);the National Natural Science Foundation of China (Grant No.11774168).
Sonoporation,or the use of ultrasound in the presence of cavitation nuclei to induce plasma membrane perforation,is well considered as an emerging physical approach to facilitate the delivery of drugs and genes to liv...
sponsored by National Key Research and Development Plan(No.2017YFC0107300 and No.2017YFC0107303)
Objective: To explore the safety of ultrasound and microbubbles for enhancing the chemotherapeutic sensitivity of malignant tumors in the digestive system in a clinical trial, as well as its efficacy.Methods: From O...
Hepatic fibrosis develops as a wound-healing scar in response to acute and chronic liver inflammation and can lead to cirrhosis in patients with chronic hepatitis B and C. The condition arises due to increased synthes...
Projects supported by the National Natural Science Foundation of China(Grant Nos.11174077 and 11474090);the Natural Science Foundation of Hunan Province,China(Grant No.13JJ3076);the Science Research Program of Education Department of Hunan Province,China(Grant No.14A127);the Doctoral Fund of University of South China(Grant No.2011XQD46)
A model of an ultrasound-driven encapsulated microbubble(EMB) oscillation near biomaterial wall is presented and used for describing the microflow-induced shear stress on the wall by means of a numerical method. The...
Projects supported by the National Basic Research Program,China(Grant No.2011CB707900);the National Natural Science Foundation of China(Grant Nos.81127901,81227004,81271589,11374155,11161120324,11074123,11174141,11274170,11104140,11474001,and 11474161);the National High Tech Research and Development Program,China(Grant No.2012AA022702);the Program for New Century Excellent Talents in University of Ministry of Education of China(Grant No.NCET-11-0236)
Sonoporation mediated by microbubbles is being extensively studied as a promising technology to facilitate gene/drug delivery to cells. However, the theoretical study regarding the mechanisms involved in sonoporation ...
Genes can be transferred using viral or non-viral vectors.Non-viral methods that use plasmid DNA and short interference RNA(si RNA)have advantages,such as low immunogenicity and low likelihood of genomic integration i...
Apoptosis is a physiologically essential mechanism of cell and plays an important role in reducing the development and progression of tumors. The appealing strategy for cancer therapy is to target the lesions that ind...
Ultrasonic imaging is becoming the most popular medical imaging modality,owing to the low price per examination and its safety.However,blood is a poor scatterer of ultrasound waves at clinical diagnostic transmit freq...
The aim of the study was to assess if low-frequency ultrasound (US), in the range of 30-35 kHz, increases non-viral gene transfer to the mouse lung. US is greatly attenuated in the lung due to large energy losses at...