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作品数：988被引量：2141H指数：19
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Plasma circulating cell–free DNA integrity and relative telomere length as diagnostic biomarkers for Parkinson's disease and multiple system atrophy:a cross-sectional study
《Neural Regeneration Research》2025年第12期3553-3563,共11页Chao Ying Chao Han Yuan Li Mingkai Zhang Shuying Xiao Lifang Zhao Hui Zhang Qian Yu Jing An Wei Mao Yanning Cai 
supported by the National Key Research and Development Program of China,No.2021YFC2501205(to YC);the Science and Technology Innovation 2030 project,No.2021ZD0201101(to YC);the National Natural Science Foundation of China,Nos.82201409(to YL),82201401(to CH);the Xuanwu Youth Development Project,No.QNPY2021011(to CH)。
In clinical specialties focusing on neurological disorders,there is a need for comprehensive and integrated non-invasive,sensitive,and specific testing methods.Both Parkinson's disease and multiple system atrophy are ...
关键词：biomarkers cell-free DNA diagnosis multiple system atrophy neurodegenerative diseases Parkinson’s disease risk factors 
Blood diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis被引量：1
《Neural Regeneration Research》2025年第9期2556-2570,共15页Yongting Lv Hongfu Li 
Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely limited.The principal pathological alterations of the disease include the selective d...
关键词：amyotrophic lateral sclerosis BIOMARKER blood biomarkers diagnosis glial fibrillary acidic protein neurofilament light chain PROGNOSIS TAR DNA-binding protein 43 
Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases
《Neural Regeneration Research》2025年第8期2373-2381,共9页Lifang Zhao Mingkai Zhang Qimeng Li Xuemin Wang Jie Lu Ying Han Yanning Cai 
supported by the National Key Research&Development Program of China,Nos.2021YFC2501205(to YC),2022YFC24069004(to JL);the STI2030-Major Project,Nos.2021ZD0201101(to YC),2022ZD0211800(to YH);the National Natural Science Foundation of China(Major International Joint Research Project),No.82020108013(to YH);the Sino-German Center for Research Promotion,No.M-0759(to YH);a grant from Beijing Municipal Science&Technology Commission(Beijing Brain Initiative),No.Z201100005520018(to JL)。
Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is k...
关键词：Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein NEURODEGENERATION neurofilament light chain plasma biomarkers single molecule array storage time tau 
MicroRNAs as potential diagnostic biomarkers for bipolar disorder
《Neural Regeneration Research》2025年第6期1681-1695,共15页Bridget Martinez Philip V.Peplow 
Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarke...
关键词：BIOMARKER bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines MICRORNA neural progenitor cells whole blood 
Recurrent acute pancreatitis and primary hyperparathyroidism in patients presenting to the emergency department:Diagnostic challenges
《World Journal of Clinical Cases》2025年第17期1-6,共6页Faruk Danış Emre Kudu 
We read the article by Karim MM et al discusses the presentation of primary hyperparathyroidism as recurrent acute pancreatitis,a rare clinical condition in pediatric patients presenting to the emergency department.As...
关键词：PANCREATITIS Recurrent pancreatitis Primary hyperparathyroidism HYPERCALCEMIA Emergency medicine Pediatric pancreatitis Parathyroid adenoma Abdominal pain Multidisciplinary approach Imaging techniques 
On-device diagnostic recommendation with heterogeneous federated BlockNets
《Science China(Information Sciences)》2025年第4期29-45,共17页Minh Hieu NGUYEN Thanh Trung HUYNH Thanh Toan NGUYEN Phi Le NGUYEN Hien Thu PHAM Jun JO Thanh Tam NGUYEN 
supported by ARC Discovery Early Career Researcher Award(Grant No.DE200101465);ARC DP Project(Grant No.DP240101108)。
The evolution of edge computing has advanced the accessibility of E-health recommendation services,encompassing areas such as medical consultations,prescription guidance,and diagnostic assessments.Traditional methodol...
关键词：intelligent recommendation federated learning heterogeneous devices E-health diagnostics 
Reanalysis of whole genome sequencing ends a diagnostic odyssey of neurodevelopmental disorders caused by RNU4-2 variants
《Science China(Life Sciences)》2025年第4期1194-1196,共3页Shiqi Fan Shuanghao Yang Miao Sun Weiyue Gu Xue Zhang 
supported by the National Key Research and Development Program of China(2022YFC2703900);the CAMS Innovation Fund for Medical Sciences(2021-I2M-1018);the National Natural Science Foundation of China(82394420 and 82394423);the Theranostics and Translational Research Facility of National Infrastructures for Translational Medicine,Institute of Clinical Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College for the support。
Dear Editor,Neurodevelopmental disorders(NDD)are a group of diseases with high phenotypic heterogeneity characterized by inability in cognition,communication,psychological skills,and motor development.The common types...
关键词：diagnostic odyssey autism spectrum disorder asd attention deficit hyperactivity REANALYSIS rnu variants whole genome sequencing neurodevelopmental disorders 
Cytochrome P4503A gene family in gastric cancer:Unveiling diagnostic biomarkers and therapeutic targets for personalized treatment
《World Journal of Clinical Oncology》2025年第4期31-43,共13页Jun-Kun Zhu Jing Wang 
The cytochrome P4503A(CYP3A)gene family’s role in early progression of gastric cancer was comprehensively investigated.Its potential as a therapeutic target was evaluated.Upon literature review,aberrant expression of...
关键词：Gastric cancer Cytochrome P4503A Early diagnosis Therapeutic target Precision medicine 
Ruminal‑buccal microbiota transmission and their diagnostic roles in subacute rumen acidosis in dairy goats
《Journal of Animal Science and Biotechnology》2025年第2期895-912,共18页Tao Liu Jingyi Xu Xiaodong Chen Jianrong Ren Jinhui He Yue Wang Yangchun Cao Le Luo Guan Junhu Yao Shengru Wu 
supported by the National Key Research and Development Program for International Science and Technology Innovation Cooperation between Governments(2023YFE0111800);the Shaanxi Province’s San Qin Talent Attraction Program for Regional Youth Talents.
Background Subacute rumen acidosis(SARA)is a common metabolic disorder in ruminants that disrupts the rumen microbiome and animal health,but diagnosis is challenging due to subtle symptoms and invasive testing require...
关键词：Dairy goats Diagnosis Oral microbiota Ruminal microbiota Subacute rumen acidosis 
Identification of hypermethylated CpG sites mapped to LIFR as specific diagnostic biomarkers of colon cancer
《Genes & Diseases》2025年第2期98-101,共4页Ruizhi Chang Ganxun Li Guan-nan Jin Bixiang Zhang Ze-yang Ding 
supported by the National Nature Science Foundation of China (No.82273441,81874065);the National Basic Research Program of China (No.2020YFA0710700);the Knowledge Innovation Program of Wuhan-Shuguang Project (China) (No.2022020801020456);Tongji Hospital (HUST)Foundation for Excellent Young Scientist (China) (No.2020YQ05);the First Level of the Public Health Youth Top Talent Project of Hubei Province (China) (No.2022SCZ051).
Despite the improvement of programmatic screening,adjuvant chemotherapy,and curative resection,colon cancer,with increasing incidence and mortality rates,still poses a significant public health challenge as the third ...
关键词：COLON cancer MORTALITY 
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