血浆同型半胱氨酸与帕金森病临床关系的研究  

Study of Serum Homocysteine Level and Parkinson's Disease

作　　者：张丽[1] 孙萍[1] 谷莹丽[1] 刘丽娜[1] 陈团团[1] 

机构地区：[1]哈尔滨医科大学附属第四医院神经内科,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2015年第19期3660-3663,共4页Progress in Modern Biomedicine

基　　金：黑龙江省卫生厅基金项目(2007-431)

摘　　要：目的:探讨帕金森病(PD)患者血浆同型半胱氨酸(Hcy)的变化及其与PD严重程度、运动、认知及抑郁之间的相关性。方法:比较53例PD患者及正常对照组血浆Hcy及维生素B12、叶酸水平。并对血浆Hcy与叶酸及维生素B12水平进行相关性分析。采用统一的Hoehn and Yahr(修正)分期量表(H&Y)、PD评价量表(UPDRS)运动分量表(UPDRS III)、简易智能精神量表(MMSE)、汉密尔顿抑郁量表(HMDS)对PD患者进行评分,分析Hcy与PD患者严重程度、运动、认知功能及抑郁的相关性。结果:PD组及对照组的Hcy浓度分别是(16.2±3.1)、(10.1±2.6)μmol/L,PD组血浆Hcy明显高于对照组,差异有统计学意义(P<0.05)。相关分析示被检者血浆Hcy水平与叶酸及维生素B12水平存在负相关。PD患者Hcy水平与H&Y、UPDRSIII、MMSE、HMDS评分具有显著性相关(分别为r=0.483,r=0.525,r=-0.429,r=0.481,P均<0.05)。结论:PD患者血浆Hcy水平升高,与维生素B12、叶酸呈负相关。PD患者Hcy水平和疾病严重程度、运动、认知程度、抑郁倾向相关。Objective： To study the relationship between the homocysteine （Hcy） levels and disease severity, movement disorders, cognitive status and depression in patients with Parkinson＇s disease （PD）. Methods： The serum homocysteine, folic acid and vitamin B^2 levels of 53 PD patients and normal control were compared. The modified Hoehn and Yahr staging scale （H＆ Y）, Unified Parkinson＇s disease Rating Scale part III （UPDRSIII）, mini-mental state examination （MMSE） and Hamilton Depression Rating Scale （HMDS） was compared between two groups, and the correlation between Hcy levels and disease severity, movement dysfunction, cognitive impairment, depression in patients with PD was analyzed. Results： The patients in PD group （16.2＋ 3.1） p^mol/L has significantly higher Hey levels compared to the control group （10.1 ~ 2.6） ixmol/L （P〈0.05）. Correlation analysis found that the plasma level of Hey was negatively correlated with the plasma levels of folate and vitamin B12. There was significant correlation between Hey levels and H＆Y, UPDRS Ill, MMSE,HMDS score in patients with PD （respectively r=0.483 ,r=0.525 ,r=-0.429,r=0.481, P〈0.05）. Conclusions： The serum Hcy level in PD patients is elevated and negatively correlated with folate and vitamin B12, and correlated with the disease severity, movement dysfunction, cognitive impairment, depression tendencies of patients.

关 键 词：同型半胱氨酸 帕金森病 运动障碍 认知障碍 抑郁 

分 类 号：R742.5[医药卫生—神经病学与精神病学]