多巴胺、5-羟色胺通路相关基因及家庭环境对创造力的影响及其作用机制  

The Genetic Basis of Creativity in Dopamine and 5-hydroxytryptamine Pathway and the Moderating Effect of Family Environment

作　　者：张景焕[1] 张木子[1] 张舜[1] 任菲菲[1] 

机构地区：[1]山东师范大学心理学院,济南250014

出　　处：《心理科学进展》2015年第9期1489-1498,共10页Advances in Psychological Science

基　　金：国家自然科学基金(31470999);教育部哲学社会科学研究重大课题攻关项目(11JZD040);教育部人文社科规划基金项目(12YJA190024);"发展与教育心理学"山东省十二五特色重点学科建设项目;山东省应用基础型名校工程建设经费支持

摘　　要：创造力的遗传基础是近年来创造力研究领域的前沿和热点问题,但仍尚处于起步阶段,也未有研究系统探讨遗传与环境因素的交互作用对创造力的影响及其作用机制。本课题拟在中国汉族人群中考察多巴胺(DA)、5-羟色胺(5-HT)神经递质通路上的32个基因约700个多态性位点与创造力的关系,并首次探讨家庭环境在遗传多态性与创造力关系中的调节作用。研究内容包括:(1)通过单基因、基于通路以及基因—基因交互作用的关联分析,考察遗传多态性对创造力的影响,揭示创造力的遗传基础;(2)通过基因—环境交互作用的关联分析,考察家庭环境在遗传与创造力关系中的调节作用;(3)通过结构方程模型的比较分析,揭示遗传与家庭环境在创造力两个方面(创造思维与创造人格)共享的与特异的作用机制。该项目成果能够从遗传与环境交互作用的角度阐明创造力个体差异的原因,有助于构建基于创造力个体差异分析的理论模型,对创造人才的鉴别和培养具有重要现实意义。Identification and exploration of the genetic basis of creativity as well as the possible mechanism through which they interact with environmental factors to contribute to creativity has been a leading issue in creativity research. The overarching goal of this project is to investigate the effect of about 700 SNPs on 32 genes in dopamine （DA） and 5-hydroxytryptamine （5-HT） pathway on creativity in the Han Chinese population, and to explore and characterize the interaction of the above genetic polymorphisms and family environmental factors in contributing to creativity. It is designed that one thousand university students participate in this project and three specific aims are expected： （1） To examine associations between creativity and genetic polymorphisms in DA and 5-HT pathways through three levels of association analysis （single gene association analysis, pathway-based association analysis and gene-gene interaction association analysis）. （2） To examine the moderating effect of family environmental factors （including family’s socioeconomic status, family atmosphere and parenting style ） on the relationship between the above genetic polymorphisms and creativity. （3） To examine the common and differential mechanism of creative thinking and creative personality. It is expected that this project will advance our understanding of creativity from the perspective of the interactions between genetic and environmental factors, and will further help to construct a theoretical model based on analysis of creativity individual differences and also help to provide some useful insight into creativity assessing and cultivating.

关 键 词：创造力 多巴胺 5-羟色胺 家庭环境 

分 类 号：B845[哲学宗教—心理学]