组织工程韧带的研究进展  

RESEARCH PROGRESS OF TISSUE ENGINEERED LIGAMENT

作　　者：孙正宇[1] 李箭[1] 

机构地区：[1]四川大学华西医院骨科,成都610041

出　　处：《中国修复重建外科杂志》2015年第9期1160-1166,共7页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的对组织工程韧带的研究进展进行综述。方法广泛查阅近年来有关组织工程韧带构建及其在前交叉韧带(anterior cruciate ligament,ACL)损伤中应用的文献,对构建相关的种子细胞、支架材料、生长因子和力学刺激的研究进展进行总结。结果利用MSCs和ACL成纤维细胞构建的组织工程韧带目前已成功应用于动物实验。选择合适的种子细胞、支架材料、力学刺激及必要的细胞因子是构建良好组织工程韧带的关键。培养条件的进一步优化以及如何实现组织工程韧带在体内更好的存活和转归,尚需进一步研究。结论组织工程韧带构建及其在ACL的修复再生方面取得了巨大进步,随着生物化学及支架材料的发展其有望用于临床。Objective To review the research progress of tissue engineered ligament. Methods The literature in recent years on tissue engineered ligament in repair of anterior cruciate ligament （ACL） injury was extensively reviewed, including cell sources, scaffold materials, growth factors, and mechanical stimulation in tissue engineered ligament. Results Tissue engineered ligament constructed by mesenchymal stem cells and ACL fibroblasts has been successfully used in animal experiments. It is crucial for qualified tissue engineered ligament to choose appropriate seed cells, scaffold, mechanical stimulation, and essential cytokines. To further optimize culture condition and how to realize the tissue engineered ligament in vivo better survival and prognosis need to be further studied. Conclusion Enormous progress has been made in tissue engineered ligament for repair and regeneration of ACL. With the development of biochemistry and scaffold materials, tissue engineered ligament will be used in clinic in the near future.

关 键 词：组织工程韧带 成纤维细胞 MSCS 支架材料 生长因子 

分 类 号：R318.08[医药卫生—生物医学工程]