周围神经损伤修复微环境的研究进展  

RESEARCH PROGRESS OF MICROENVIRONMENT FOR TREATMENT OF PERIPHERAL NERVOUS INJURIES

作　　者：姚东东[1,2] 张洁元[1] 刘彬[2] 李兵仓[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所创伤烧伤与复合伤国家重点实验室,重庆400042 [2]西南大学生命科学学院淡水鱼类资源与生殖发育教育部重点实验室

出　　处：《中国修复重建外科杂志》2015年第9期1167-1172,共6页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(81371341);国家重点基础研究发展计划(973)资助项目(2012CB518106);创伤;烧伤与复合伤国家重点实验室Ⅰ类研究课题(SKLZZ201003)~~

摘　　要：目的对周围神经损伤修复微环境的研究进展作一综述。方法广泛查阅近年来周围神经损伤后修复机制的相关文献,对其修复过程中的微环境变化进行综述。结果周围神经损伤后的修复过程依赖于损伤神经所在的微环境,包括神经再生通道建立、神经营养因子调节、炎性反应、激素调节、信号通路调控及酶的调节,对其深入研究有助于在细胞和分子水平上深入了解周围神经损伤后神经元胞体轴突近远端的变化。结论周围神经损伤后其修复微环境的研究取得了显著进展,结合纳米技术、材料科学、基因工程和干细胞移植等技术,可为临床治疗提供新的思路和依据。Objective To review the research progress of microenvironment for the treatment of peripheral nervous injuries. Methods The recent literature concerning the treatment mechanism of peripheral nervous injuries was extensively consulted, and the microenvironment response involved in the treatment of peripheral nervous injuries was reviewed. Results The complex microenvironment for treatment of peripheral nervous injuries is dependent on nerve regeneration chamber, the formation of neurotrophic factors, inflammation response, regulation of hormones, signaling pathways, and related enzymes in regulation. In-depth study will help us have a clearer understanding on the distal and proximal neurons axons at the cellular and molecular levels after peripheral nervous injuries. Condusion In recent years, the researches of microenvironment for the treatment of peripheral nervous injuries have achieved obvious progress. With the current nanotechnology, materials science, genetic engineering, and stern cell transplantation technology, it will provide new ideas and corresponding basis for clinical treatment.

关 键 词：周围神经 损伤修复 炎性反应 信号通路 微环境 

分 类 号：R745[医药卫生—神经病学与精神病学]