睑板腺管按摩治疗睑板腺功能障碍的临床观察  

Effectiveness of Meibomian Gland Tube Massage in Treating Meibomian Gland Dysfunction

作　　者：陈国玲[1] 考欣 张晗[1] 肖瑛[1] 刘少华[1] 马广凤 侯静[1] 

机构地区：[1]山东大学第二医院眼科山东大学眼科中心,济南250033

出　　处：《中国医学科学院学报》2015年第4期415-419,共5页Acta Academiae Medicinae Sinicae

基　　金：山东省科技发展计划(2014GSF118006)~~

摘　　要：目的观察睑板腺管按摩治疗睑板腺功能障碍(MGD)的临床疗效。方法将60例MGD患者采用随机数字表的方法分为药物组和按摩组,药物组局部应用糖皮质激素眼膏和人工泪液,按摩组在睑板腺按摩的基础上给予上述药物。分别于治疗前、治疗后2周和4周对患者进行裂隙灯显微镜及眼压检查,记录眼表疾病指数(OSDI)调查问卷、泪膜破裂时间(TBUT)、角膜荧光素染色(CFS)和泪液分泌试验(SIt)等检查结果。结果两组患者治疗前的OSDI、CFS、TBUT及SIt结果差异均无统计学意义(P均>0.05)。两种治疗方法均可明显改善MGD患者眼部症状、延长泪膜破裂时间、增加泪液试纸湿润长度、改善角膜损伤程度,与治疗前相比差异有统计学意义(P均<0.05);除CFS治疗后4周外,按摩组的疗效均优于治疗后同时间点的药物组,差异有统计学意义(P均<0.01)。结论睑板腺管按摩联合药物治疗可提高MGD的临床疗效。Objective To observe the clinical effectiveness of meibomian gland tube massage in treating meibomian gland dysfunction（ MGD）. Methods All patients were divided into medicine group（ tropically administered with corticosteroid eye ointment and artificial tears） and massage group（ meibomian gland tube massage in addition to these drugs） using random numbers. At different period（ before treatment and after treatment 2,4 weeks）,the slip-lamp microscopy and intraocular pressure measurement were performed. Ocular symptoms were evaluated by questionnaire of ocular surface disease index（ OSDI）, and corneal fluorescein staining scores（ CFS） was used for checking the epithelial integrity,tear film breakup time（ TBUT）,and tear secretion（ Schirmer I test, SIt）. Results Before the treatment, the OSDI score, TBUT, CFS, and SIt showed no statistical significance between these two groups（ all P〉0. 05）. After the treatment, thesymptoms,damage of corneal epithelium,quality of tear film,tear secretion were significantly improved in both groups（ P〈0. 05）,and were significantly superior in the massage group than in the medicine group（ all P〈0. 01; but CFS t4w= 6. 60,P〉0. 05）. Conclusion The meibomian gland tube massage in combination with drug therapy can improve the treatment effectives for MGD.

关 键 词：睑板腺功能障碍 按摩 疗效 

分 类 号：R777.2[医药卫生—眼科]